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There are many clinical methods to alleviate HS, but most of them are accompanied by many complications. To investigate the effects of \u03b2\u2010Elemene, extracted from the ginger family plant Wenyujin, on human hypertrophic scar fibroblast (hHSFs). Cultured hHSFs and human normal fibroblasts, observed the effect of \u03b2\u2010Elemene on apoptosis, extracellular matrix, and endoplasmic reticulum stress (ERS) by western blot, Real Time\u2010Polymerase Chain Reaction (RT\u2010PCR), and flow cytometry. Based on our findings, it is clear that \u03b2\u2010Elemene could inhibit the expression of \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA), collagen I, and fibronectin, reduced collagen deposition. Further studies had found that \u03b2\u2010Elemene could increase the expression of ERS\u2010related proteins CHOP and Calnexin in a dose\u2010dependent manner, thereby promoting the aggregation of cleaved\u2010caspase\u20103 and inducing hHSFs to undergo poptosis. This process may depend on the regulation of P53. The results of our study indicates that \u03b2\u2010Elemene induced hHSFs to undergo apoptosis though ERS pathway in a P53\u2010dependent manner, which means that our research provided a new strategy for the development of drugs for the treatment of HS.<\/jats:p>","DOI":"10.1002\/iub.2614","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T14:51:00Z","timestamp":1647442260000},"page":"508-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>\u03b2\u2010Elemene<\/scp> induces apoptosis by activating the <scp>P53<\/scp> pathway in human hypertrophic scar fibroblasts"],"prefix":"10.1002","volume":"74","author":[{"given":"Qin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing 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