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Uncontrolled diabetes predisposes an individual to develop fatal complications like cardiovascular disorders, kidney damage, and neuropathies and aggravates the severity of treatable infections. Escalating cases of Type 1 and Type 2 diabetes correlate with a global upswing in diabetes\u2010linked mortality. As a growing global concern with limited preventive interventions, diabetes necessitates extensive research to mitigate its healthcare burden and assist ailing patients. An altered immune system exacerbated by chronic hyperinflammation heightens the susceptibility of diabetic individuals to microbial infections, including notable viruses like SARS\u2010CoV\u20102, dengue, and influenza. Given such a scenario, we scrutinized the literature and compiled molecular pathways and signaling cascades related to immune compartments in diabetics that escalate the severity associated with the above\u2010mentioned viral infections in them as compared to healthy individuals. The pathogenesis of these viral infections that trigger diabetes compromises both innate and adaptive immune functions and pre\u2010existing diabetes also leads to heightened disease severity. Lastly, this review succinctly outlines available treatments for diabetics, which may hold promise as preventive or supportive measures to effectively combat these viral infections in the former.<\/jats:p>","DOI":"10.1002\/iub.2794","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T16:13:30Z","timestamp":1702052010000},"page":"242-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Viral infection and host immune response in diabetes"],"prefix":"10.1002","volume":"76","author":[{"given":"Garima","family":"Joshi","sequence":"first","affiliation":[{"name":"Regional Centre for Biotechnology National Capital Region Biotech Science Cluster  Faridabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Das","sequence":"additional","affiliation":[{"name":"Regional Centre for Biotechnology National Capital Region Biotech Science Cluster  Faridabad 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