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We previously established a platform for identifying Food and Drug Administration (FDA)\u2010approved repurposed drugs for avian influenza A virus infections that could be used for coronavirus disease 2019 (COVID\u201019) treatment. In this study, we analyzed blood samples from two cohorts of 63 COVID\u201019 patients, including 19 patients with severe disease. Among the 39 FDA\u2010approved drugs we identified for COVID\u201019 therapy in both cohorts, 23 drugs were confirmed by literature mining data, including 14 drugs already under COVID\u201019 clinical trials and 9 drugs reported for COVID\u201019 treatments, suggesting the remaining 16 FDA\u2010approved drugs may be candidates for COVID\u201019 therapy. Additionally, we previously reported that herbal small RNAs (sRNAs) could be effective components in traditional Chinese medicine (TCM) for treating COVID\u201019. Based on the abundance of sRNAs, we screened the 245 TCMs in the Bencao (herbal) sRNA Atlas that we had previously established, and we found that the top 12 TCMs for COVID\u201019 treatment was consistent across both cohorts. We validated the efficiency of the top 30 sRNAs from each of the top 3 TCMs for COVID\u201019 treatment in poly(I:C)\u2010stimulated human non\u2010small cell lung cancer cells (A549 cells). In conclusion, our study recommends potential COVID\u201019 remedies using FDA\u2010approved repurposed drugs and herbal sRNAs from TCMs.<\/jats:p>","DOI":"10.1002\/iub.2860","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T09:07:02Z","timestamp":1719392822000},"page":"960-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential <scp>COVID<\/scp>\u201019 remedies from repurposed drugs and herbal small <scp>RNAs<\/scp>"],"prefix":"10.1002","volume":"76","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology  Shenzhen 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