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Here, we studied the biological activity of lectins from the mussels <jats:italic>Crenomytilus graynus<\/jats:italic> (CGL) and <jats:italic>Mytilus trossulus<\/jats:italic> (MTL) and showed that these proteins can affect the proliferation of human lymphoma cells. Both lectins suppressed the formation of colonies as well as cell cycle progression. The mechanism of action of these lectins was not mediated by reactive oxygen species but included damaging of mitochondria, inhibition of key cell cycle points, and activation of MAPK signaling pathway in tumor cells. Computer modeling suggested that various effects of CGL and MTL on lymphoma cells may be due to the difference in the energy of binding of these lectins to carbohydrate ligands on the cell surface. Thus, molecular recognition of residues of terminal carbohydrates on the surface of tumor cells is a key factor in the manifestation of the biological action of lectins.<\/jats:p>","DOI":"10.1002\/iub.2909","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:40:56Z","timestamp":1724294456000},"page":"1279-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lectins <scp>CGL<\/scp> and <scp>MTL<\/scp>, representatives of mytilectin family, exhibit different antiproliferative activity in Burkitt's lymphoma cells"],"prefix":"10.1002","volume":"76","author":[{"given":"Alexandra S.","family":"Kuzmich","sequence":"first","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina P.","family":"Filshtein","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina N.","family":"Likhatskaya","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Y.","family":"Gorpenchenko","sequence":"additional","affiliation":[{"name":"Federal Scientific Center of the East Asia Terrestrial Biodiversity Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina V.","family":"Chikalovets","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana O.","family":"Mizgina","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences  Vladivostok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-8299","authenticated-orcid":false,"given":"Kuo\u2010Feng","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science National Ilan University  Yilan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhild","family":"von Amsberg","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald\u2010Tumorzentrum University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Martini\u2010Klinik, Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-9245","authenticated-orcid":false,"given":"Sergey A.","family":"Dyshlovoy","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald\u2010Tumorzentrum University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-3637","authenticated-orcid":false,"given":"Oleg V.","family":"Chernikov","sequence":"additional","affiliation":[{"name":"G.B. 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