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Mesenchymal stem cell (MSC) therapy has shown great promise as a disease\u2010modifying solution for PD. Induced pluripotent stem cell\u2010derived MSC (iMSC) not only has stronger neural repair function, but also helps solve the problem of MSC heterogeneity. So we evaluated the therapeutic effects of iMSCs on PD. iMSCs were administered by tail vein in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2010induced PD models of C57BL\/6 mice. The results showed iMSCs increased body weights, inhibited the prolongation of latencies to descend in pole tests, the decrease of grip strength in grip strength tests and increase of open arm entries in elevated plus maze test, and showed a trend to alleviate striatal dopamine loss. They indicate iMSCs might improve functions partially by preserving striatal dopamine in PD. We for the first time (1) found that iMSC has therapeutic effects on PD; (2) tested specifically muscle strength in cell therapy for PD and found it increases muscle strength; (3) found cell therapy alleviated the increase of entries into the open arms in PD. It suggests iMSC is a promising candidate for clinical investigations and drug development for PD.<\/jats:p>","DOI":"10.1002\/iub.2936","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T13:29:03Z","timestamp":1735565343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The therapeutic effects of induced pluripotent stem cell\u2010derived mesenchymal stem cells on Parkinson's disease"],"prefix":"10.1002","volume":"77","author":[{"given":"Hao","family":"Ren","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hunan University  Changsha China"},{"name":"Cheerland Watson Precision Medicine Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Cheerland Watson Precision Medicine Ltd  Shenzhen 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