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In this study, we investigated the effect of MK\u20104 upon the proliferation of rheumatoid synovial cells and the development of arthritis in collagen\u2010induced arthritis (CIA). We analyzed the effect of MK\u20104 on the proliferation of fibroblast\u2010like synoviocytes (FLSs) using the3\u2010(4,5\u2010demethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT) assay. The proapoptotic effect of MK\u20104 upon FLS was investigated with annexin V staining and DNA fragmentation and caspase 3\/7 assays. Moreover, we analyzed the effect of MK\u20104 on the development of CIA in female dark agouti rats. Our results indicated that MK\u20104 inhibited the proliferation of FLS and the development of CIA in a dose\u2010dependent manner. We concluded that MK\u20104 may represent a new agent for the treatment of RA in the setting of combination therapy with other disease\u2010modifying antirheumatic drugs. \u00a9 2008 IUBMB IUBMB Life, 60(6): 355\u2013361, 2008<\/jats:p>","DOI":"10.1002\/iub.41","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T16:18:08Z","timestamp":1210868288000},"page":"355-361","source":"Crossref","is-referenced-by-count":25,"title":["Vitamin K and rheumatoid arthritis"],"prefix":"10.1002","volume":"60","author":[{"given":"Hiroshi","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0281355"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0021-9258(20)65217-6","article-title":"Purification of the antihemorrhagic vitamin","volume":"114","author":"Almquist H. 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