{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:17:09Z","timestamp":1777501029483,"version":"3.51.4"},"reference-count":93,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Impaired kidney function and subsequent skeletal responses play a critical role in disrupting phosphate balance in chronic kidney disease (CKD) patients with mineral and bone disorder (CKD\u2010MBD). In patients with CKD\u2010MBD, the inability of the kidney to maintain normal mineral ion balance affects bone remodeling to induce skeletal fracture and extraskeletal vascular calcification. In physiological conditions, bone\u2010derived fibroblast growth factor 23 (FGF23) acts on the kidney to reduce serum phosphate and 1,25\u2010dihydroxyvitamin D levels. In humans, increased bioactivity of FGF23 leads to increased urinary phosphate excretion, which induces hypophosphatemic diseases (e.g., rickets\/osteomalacia). However, reduced FGF23 activity is associated with hyperphosphatemic diseases (e.g., tumoral calcinosis). In patients with CKD, high serum levels of FGF23 fail to reduce serum phosphate levels and lead to numerous complications, including vascular calcification, one of the important determinants of mortality of CKD\u2010MBD patients. Of particular significance, molecular, biochemical and morphological changes in patients with CKD\u2010MBD are mostly due to osteo\u2010renal dysregulation of mineral ion metabolism. Furthermore, hyperphosphatemia can partly contribute to the development of secondary hyperparathyroidism in patients with CKD\u2010MBD. Relatively new pharmacological agents including sevelamer hydrochloride, calcitriol analogs and cinacalcet hydrochloride are used either alone, or in combination, to minimize hyperphosphatemia and hyperparathyroidism associated complications to improve morbidity and mortality of CKD\u2010MBD patients. This article will briefly summarize how osteo\u2010renal miscommunication can induce phosphate toxicity, resulting in extensive tissue injuries. \u00a9 2011 IUBMB IUBMB Life, 63(4): 240\u2013247, 2011<\/jats:p>","DOI":"10.1002\/iub.437","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T16:13:10Z","timestamp":1300983190000},"page":"240-247","source":"Crossref","is-referenced-by-count":30,"title":["Osteo\u2010renal regulation of systemic phosphate metabolism"],"prefix":"10.1002","volume":"63","author":[{"given":"Mohammed Shawkat","family":"Razzaque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,24]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.001"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq721"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90538.2008"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0230-3"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.196"},{"key":"e_1_2_9_7_2","first-page":"613","article-title":"Disorders of calcium, phosphorus and magnesium metabolism","volume":"56","author":"Ghosh A. 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