{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:22:01Z","timestamp":1790680921117,"version":"4.1.0"},"reference-count":109,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1704,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1002\/iub.512","type":"journal-article","created":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T18:44:46Z","timestamp":1313001886000},"page":"n\/a-n\/a","source":"Crossref","is-referenced-by-count":4,"title":["Intracellular trafficking of the \u03b2-secretase and processing of amyloid precursor protein"],"prefix":"10.1002","author":[{"given":"Pei","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,10]]},"reference":[{"key":"10.1002\/iub.512-BIB1|cit1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1034\/j.1600-0854.2000.011104.x","article-title":"Traffic jam: a compendium of human diseases that affect intracellular transport processes","volume":"1","author":"Aridor","year":"2000","journal-title":"Traffic"},{"key":"10.1002\/iub.512-BIB2|cit2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0074-7696(07)61002-X","article-title":"New insights into membrane trafficking and protein sorting","volume":"261","author":"Derby","year":"2007","journal-title":"Int. Rev. Cytol."},{"key":"10.1002\/iub.512-BIB3|cit3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.2945253","article-title":"The trans Golgi network: sorting at the exit site of the Golgi complex","volume":"234","author":"Griffiths","year":"1986","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB4|cit4","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1242\/jcs.110.24.3001","article-title":"Post-Golgi biosynthetic trafficking","volume":"110","author":"Keller","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1002\/iub.512-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(01)00428-7","article-title":"Endocytosis and signaling. An inseparable partnership","volume":"106","author":"Di Fiore","year":"2001","journal-title":"Cell"},{"key":"10.1002\/iub.512-BIB6|cit6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0955-0674(03)00077-2","article-title":"Retrograde traffic in the biosynthetic-secretory route: pathways and machinery","volume":"15","author":"Sannerud","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1002\/iub.512-BIB7|cit7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0955-0674(97)80029-4","article-title":"The trans-Golgi network-a late secretory sorting station","volume":"9","author":"Traub","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1002\/iub.512-BIB8|cit8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1091\/mbc.E04-03-0260","article-title":"Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'","volume":"16","author":"Young","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1002\/iub.512-BIB9|cit9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrm2755","article-title":"Pathways and mechanisms of endocytic recycling","volume":"10","author":"Grant","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1002\/iub.512-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2008.12.009","article-title":"Tracing the retrograde route in protein trafficking","volume":"135","author":"Johannes","year":"2008","journal-title":"Cell"},{"key":"10.1002\/iub.512-BIB11|cit11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1002\/iub.512-BIB12|cit12","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB13|cit13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"key":"10.1002\/iub.512-BIB14|cit14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1738846","article-title":"Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor","volume":"255","author":"Estus","year":"1992","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB15|cit15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/361260a0","article-title":"Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide","volume":"361","author":"Seubert","year":"1993","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers-a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1002\/iub.512-BIB17|cit17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2007.10.012","article-title":"Presenilin: running with scissors in the membrane","volume":"131","author":"Selkoe","year":"2007","journal-title":"Cell"},{"key":"10.1002\/iub.512-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.2111583","article-title":"Cleavage of amyloid beta peptide during constitutive processing of its precursor","volume":"248","author":"Esch","year":"1990","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/NMM:1:1:1","article-title":"Advances inthe cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease","volume":"1","author":"Sambamurti","year":"2002","journal-title":"Neuromol. Med."},{"key":"10.1002\/iub.512-BIB20|cit20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","article-title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB21|cit21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/35024009","article-title":"Nicastrin modulates presenilin-mediated notch\/glp-1 signal transduction and betaAPP processing","volume":"407","author":"Yu","year":"2000","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB22|cit22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","article-title":"aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation","volume":"3","author":"Francis","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1002\/iub.512-BIB23|cit23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","article-title":"The role of presenilin cofactors in the gamma-secretase complex","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB24|cit24","first-page":"35","article-title":"Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease","volume":"41","author":"Kowalska","year":"2003","journal-title":"Folia Neuropathol."},{"key":"10.1002\/iub.512-BIB25|cit25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/mcne.1999.0811","article-title":"Identification of a novel aspartic protease (Asp 2) as beta-secretase","volume":"14","author":"Hussain","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1002\/iub.512-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.97.4.1456","article-title":"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein","volume":"97","author":"Lin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB27|cit27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/990114","article-title":"Purification and cloning of amyloid precursor protein beta-secretase from human brain","volume":"402","author":"Sinha","year":"1999","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB28|cit28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","article-title":"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB29|cit29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/990107","article-title":"Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity","volume":"402","author":"Yan","year":"1999","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB30|cit30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB31|cit31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0969-9961(03)00104-9","article-title":"BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time","volume":"14","author":"Luo","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1002\/iub.512-BIB32|cit32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/85059","article-title":"Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation","volume":"4","author":"Luo","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1002\/iub.512-BIB33|cit33","doi-asserted-by":"crossref","first-page":"20647","DOI":"10.1074\/jbc.M002688200","article-title":"Expression analysis of BACE2 in brain and peripheral tissues","volume":"275","author":"Bennett","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB34|cit34","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1096\/fj.04-3426com","article-title":"Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes","volume":"19","author":"Sun","year":"2005","journal-title":"FASEB J."},{"key":"10.1002\/iub.512-BIB35|cit35","doi-asserted-by":"crossref","first-page":"9712","DOI":"10.1073\/pnas.160115697","article-title":"BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein","volume":"97","author":"Farzan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB36|cit36","doi-asserted-by":"crossref","first-page":"34019","DOI":"10.1074\/jbc.M105583200","article-title":"BACE2 functions as an alternative alpha-secretase in cells","volume":"276","author":"Yan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB37|cit37","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1074\/jbc.M009899200","article-title":"Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane\/cytosolic domains affect its cellular activity and amyloid-beta production","volume":"276","author":"Benjannet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB38|cit38","doi-asserted-by":"crossref","first-page":"37712","DOI":"10.1074\/jbc.M005339200","article-title":"A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase","volume":"275","author":"Bennett","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB39|cit39","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1074\/jbc.M006947200","article-title":"Processing of beta-secretase by furin and other members of the proprotein convertase family","volume":"276","author":"Creemers","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB40|cit40","doi-asserted-by":"crossref","first-page":"21099","DOI":"10.1074\/jbc.M002095200","article-title":"Characterization of Alzheimer's beta-secretase protein BACE. A pepsinfamily member with unusual properties","volume":"275","author":"Haniu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB41|cit41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1389-0344(01)00098-3","article-title":"Analysis of N-linked oligosaccharides: progress towards the characterisation of glycoprotein-linked carbohydrates","volume":"18","author":"Charlwood","year":"2001","journal-title":"Biomol. Eng."},{"key":"10.1002\/iub.512-BIB42|cit42","doi-asserted-by":"crossref","first-page":"36788","DOI":"10.1074\/jbc.M104350200","article-title":"The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate","volume":"276","author":"Yan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB43|cit43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1083\/jcb.200207113","article-title":"Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts","volume":"160","author":"Ehehalt","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1002\/iub.512-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0960-9822(01)00394-3","article-title":"Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts","volume":"11","author":"Riddell","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1002\/iub.512-BIB45|cit45","doi-asserted-by":"crossref","first-page":"11735","DOI":"10.1073\/pnas.1635130100","article-title":"Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein","volume":"100","author":"Cordy","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB46|cit46","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1126\/science.1156609","article-title":"Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting","volume":"320","author":"Rajendran","year":"2008","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB47|cit47","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1074\/jbc.M808920200","article-title":"Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts","volume":"284","author":"Vetrivel","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB48|cit48","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1021\/bi9906827","article-title":"Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells","volume":"38","author":"Parvathy","year":"1999","journal-title":"Biochemistry"},{"key":"10.1002\/iub.512-BIB49|cit49","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.89.13.6075","article-title":"Beta-amyloid precursor protein cleavage by a membrane-bound protease","volume":"89","author":"Sisodia","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB50|cit50","doi-asserted-by":"crossref","first-page":"51035","DOI":"10.1074\/jbc.M304989200","article-title":"Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface","volume":"278","author":"Chyung","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB51|cit51","doi-asserted-by":"crossref","first-page":"33729","DOI":"10.1074\/jbc.M004175200","article-title":"Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase","volume":"275","author":"Huse","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB52|cit52","doi-asserted-by":"crossref","first-page":"18851","DOI":"10.1074\/jbc.274.27.18851","article-title":"Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42","volume":"274","author":"Perez","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB53|cit53","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1242\/jcs.00643","article-title":"Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes","volume":"116","author":"Kinoshita","year":"2003","journal-title":"J. Cell Sci."},{"issue":"Pt 5","key":"10.1002\/iub.512-BIB54|cit54","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.109.5.991","article-title":"Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody","volume":"109","author":"Koo","year":"1996","journal-title":"J. Cell Sci."},{"key":"10.1002\/iub.512-BIB55|cit55","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer's disease beta-amyloid peptides are released inassociation with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB56|cit56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuron.2006.09.001","article-title":"Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis","volume":"52","author":"Small","year":"2006","journal-title":"Neuron"},{"key":"10.1002\/iub.512-BIB57|cit57","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1212\/01.wnl.0000192107.17175.39","article-title":"Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments","volume":"66","author":"Vetrivel","year":"2006","journal-title":"Neurology"},{"key":"10.1002\/iub.512-BIB58|cit58","doi-asserted-by":"crossref","first-page":"32499","DOI":"10.1074\/jbc.M506199200","article-title":"BACE is degraded via the lysosomal pathway","volume":"280","author":"Koh","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB59|cit59","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1074\/jbc.M411296200","article-title":"GGA proteins mediate the recycling pathway of memapsin 2 (BACE)","volume":"280","author":"He","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB60|cit60","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.mcn.2005.03.014","article-title":"GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network","volume":"29","author":"Wahle","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1002\/iub.512-BIB61|cit61","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2010.01.015","article-title":"Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex","volume":"18","author":"Burgos","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1002\/iub.512-BIB62|cit62","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1074\/jbc.270.8.3565","article-title":"Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain","volume":"270","author":"Lai","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB63|cit63","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","article-title":"Signals for sorting of transmembrane proteins to endosomes and lysosomes","volume":"72","author":"Bonifacino","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1002\/iub.512-BIB64|cit64","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1074\/jbc.M800642200","article-title":"Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes","volume":"283","author":"Lee","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB65|cit65","doi-asserted-by":"crossref","first-page":"14257","DOI":"10.1074\/jbc.M801531200","article-title":"A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein","volume":"283","author":"Schobel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB66|cit66","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tins.2006.03.001","article-title":"The X11 proteins, Abeta production and Alzheimer's disease","volume":"29","author":"Miller","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1002\/iub.512-BIB67|cit67","doi-asserted-by":"crossref","first-page":"36032","DOI":"10.1074\/jbc.M301632200","article-title":"Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein","volume":"278","author":"Hill","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB68|cit68","doi-asserted-by":"crossref","first-page":"39803","DOI":"10.1074\/jbc.C000656200","article-title":"Mints as adaptors. Direct binding to neurexins and recruitment of munc18","volume":"275","author":"Biederer","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB69|cit69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1091\/mbc.E07-05-0465","article-title":"Mint3\/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network","volume":"19","author":"Shrivastava-Ranjan","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1002\/iub.512-BIB70|cit70","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1126\/science.282.5392.1327","article-title":"A structural explanation for the recognition of tyrosine-based endocytotic signals","volume":"282","author":"Owen","year":"1998","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB71|cit71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/mcne.2001.1065","article-title":"The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)","volume":"19","author":"Pastorino","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1002\/iub.512-BIB72|cit72","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nature07422","article-title":"A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex","volume":"456","author":"Kelly","year":"2008","journal-title":"Nature"},{"key":"10.1002\/iub.512-BIB73|cit73","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm1279","article-title":"The GGA proteins: adaptors on the move","volume":"5","author":"Bonifacino","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1002\/iub.512-BIB74|cit74","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1242\/jcs.01422","article-title":"Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy","volume":"117","author":"von Arnim","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1002\/iub.512-BIB75|cit75","doi-asserted-by":"crossref","first-page":"14634","DOI":"10.1074\/jbc.M011116200","article-title":"Phosphorylation regulates intracellular trafficking of beta-secretase","volume":"276","author":"Walter","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB76|cit76","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neuron.2007.05.012","article-title":"Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity","volume":"54","author":"Tesco","year":"2007","journal-title":"Neuron"},{"key":"10.1002\/iub.512-BIB77|cit77","doi-asserted-by":"crossref","first-page":"9913","DOI":"10.1523\/JNEUROSCI.2290-06.2006","article-title":"GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing","volume":"26","author":"von Arnim","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1002\/iub.512-BIB78|cit78","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/ncb1106","article-title":"Interactions of GGA3 with the ubiquitin sorting machinery","volume":"6","author":"Puertollano","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1002\/iub.512-BIB79|cit79","doi-asserted-by":"crossref","first-page":"24108","DOI":"10.1074\/jbc.M109.092742","article-title":"Ubiquitin regulates GGA3-mediated degradation of BACE1","volume":"285","author":"Kang","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB80|cit80","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200312055","article-title":"Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor","volume":"165","author":"Arighi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1002\/iub.512-BIB81|cit81","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejcb.2009.10.021","article-title":"Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin","volume":"89","author":"Lieu","year":"2010","journal-title":"Eur. J. Cell Biol."},{"key":"10.1002\/iub.512-BIB82|cit82","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1242\/jcs.003020","article-title":"The retromer complex and clathrin define an early endosomal retrograde exit site","volume":"120","author":"Popoff","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1002\/iub.512-BIB83|cit83","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1002\/iub.512-BIB84|cit84","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/ncb1153","article-title":"The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor","volume":"6","author":"Verges","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1002\/iub.512-BIB85|cit85","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1091\/mbc.8.8.1529","article-title":"A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor","volume":"8","author":"Horazdovsky","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1002\/iub.512-BIB86|cit86","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1083\/jcb.142.3.665","article-title":"A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast","volume":"142","author":"Seaman","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1002\/iub.512-BIB87|cit87","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.cub.2004.09.077","article-title":"Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides","volume":"14","author":"Carlton","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1002\/iub.512-BIB88|cit88","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/MCB.00156-06","article-title":"Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors","volume":"27","author":"Rojas","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1002\/iub.512-BIB89|cit89","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tcb.2004.12.004","article-title":"Recycle your receptors with retromer","volume":"15","author":"Seaman","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1002\/iub.512-BIB90|cit90","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.devcel.2009.04.016","article-title":"The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network","volume":"17","author":"Wassmer","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1002\/iub.512-BIB91|cit91","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1600-0854.2008.00777.x","article-title":"The structure and function of the retromer protein complex","volume":"9","author":"Collins","year":"2008","journal-title":"Traffic"},{"key":"10.1002\/iub.512-BIB92|cit92","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ana.20667","article-title":"Model-guided microarray implicates the retromer complex in Alzheimer's disease","volume":"58","author":"Small","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1002\/iub.512-BIB93|cit93","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1002\/iub.512-BIB94|cit94","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1073\/pnas.0802545105","article-title":"Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation","volume":"105","author":"Muhammad","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB95|cit95","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1326-5-40","article-title":"Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated","volume":"5","author":"Vieira","year":"2010","journal-title":"Mol. Neurodegener"},{"key":"10.1002\/iub.512-BIB96|cit96","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.0503689102","article-title":"Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein","volume":"102","author":"Andersen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB97|cit97","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1128\/MCB.00815-07","article-title":"Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA","volume":"27","author":"Nielsen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1002\/iub.512-BIB98|cit98","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1523\/JNEUROSCI.4946-05.2006","article-title":"The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments","volume":"26","author":"Offe","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1002\/iub.512-BIB99|cit99","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.3872-10.2010","article-title":"Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex","volume":"30","author":"Lane","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1002\/iub.512-BIB100|cit100","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1096\/fj.09-146357","article-title":"Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing","volume":"24","author":"Okada","year":"2010","journal-title":"FASEB J."},{"key":"10.1002\/iub.512-BIB101|cit101","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1074\/jbc.M110.170217","article-title":"BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin","volume":"286","author":"Finan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB102|cit102","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1515\/BC.2008.125","article-title":"Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases","volume":"389","author":"Bohme","year":"2008","journal-title":"Biol. Chem."},{"key":"10.1002\/iub.512-BIB103|cit103","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.1064638","article-title":"A portrait of Alzheimer secretases-new features and familiar faces","volume":"293","author":"Esler","year":"2001","journal-title":"Science"},{"key":"10.1002\/iub.512-BIB104|cit104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1034\/j.1600-0854.2001.020201.x","article-title":"Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease","volume":"2","author":"Huse","year":"2001","journal-title":"Traffic"},{"key":"10.1002\/iub.512-BIB105|cit105","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","article-title":"Evidence that production and release of amyloid beta-protein involves the endocytic pathway","volume":"269","author":"Koo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.512-BIB106|cit106","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1073\/pnas.94.8.4125","article-title":"Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons","volume":"94","author":"Tienari","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/iub.512-BIB107|cit107","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1523\/JNEUROSCI.4396-06.2007","article-title":"Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1002\/iub.512-BIB108|cit108","first-page":"383","article-title":"Progress toward a practical BACE-1 inhibitor","volume":"10","author":"Hills","year":"2007","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/iub.512-BIB109|cit109","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/156802606776287027","article-title":"Inhibitors and modulators of beta- and gamma-secretase","volume":"6","author":"Schmidt","year":"2006","journal-title":"Curr. Top. Med. Chem."}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/iub.512\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T04:24:15Z","timestamp":1638246255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iub.512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":109,"URL":"https:\/\/doi.org\/10.1002\/iub.512","relation":{},"ISSN":["1521-6543"],"issn-type":[{"value":"1521-6543","type":"print"}],"subject":[],"published":{"date-parts":[[2011]]}}}