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This study was aimed at elucidating the role and mechanism of SNORA33 in the tumorigenesis and progression of ccRCC. The snoRNAs expression matrices were obtained from the public TCGA and SNORic databases. Kaplan\u2013Meier analysis was employed to investigate the survival of patients with ccRCC presenting different SNORA33 expression. The prognostic value of SNORA33 in ccRCC was examined using Cox univariate and multivariate analyses. A series of in\u00a0vitro experiments were conducted to explore the functional role of SNORA33 in ccRCC. Gene set enrichment analysis (GSEA) and western blot were used to explore and validate the involved mechanisms. SNORA33 was highly expressed in patients with ccRCC and was correlated with poor prognosis. In addition, SNORA33 was intimately associated with the infiltration of diverse immune cells and positively correlated with the immune score as well as the expression levels of multiple immune checkpoint molecules, serving as a potential biomarker for immunotherapy prediction. The findings of in\u00a0vitro experiments indicated that SNORA33 was capable of promoting the proliferation, invasion, migration, and resistance to sunitinib in ccRCC. SNORA33 was highly expressed in ccRCC and indicated an adverse prognosis. SNORA33 was capable of facilitating the progression, invasion, metastasis, and resistance to sunitinib of ccRCC cells through mediating the JAK\/STAT pathway.<\/jats:p>","DOI":"10.1002\/iub.70058","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:50:26Z","timestamp":1758725426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>SNORA33<\/scp> Promotes Clear Cell Renal Cell Carcinoma Development and Resistance to Sunitinib Through Triggering the <scp>JAK<\/scp>\/<scp>STAT<\/scp> Pathway"],"prefix":"10.1002","volume":"77","author":[{"given":"Jiajia","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinzheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianzhao","family":"zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7046-7982","authenticated-orcid":false,"given":"Yidong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.01.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12413"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.84067"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309359"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242606799"},{"issue":"12","key":"e_1_2_12_9_1","first-page":"882","article-title":"Reduced Accumulation of Specific microRNAs in Colorectal Neoplasia","volume":"1","author":"Michael M. 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