{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:49:51Z","timestamp":1764157791902,"version":"3.46.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreatic cancer (PC) is one of the deadliest malignancies due to early metastasis, therapy resistance, and a highly immunosuppressive microenvironment. Although oncogenic mutations such as\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>TP53<\/jats:italic>\n                    are well characterized, the role of protein tyrosine phosphatase non\u2010receptor type 14 (PTPN14)\u2014a Hippo\u2010pathway regulator implicated in other cancers\u2014remains unclear in PC. PTPN14 expression was analyzed in PC tissues and cell lines using immunohistochemistry and western blotting. Functional effects of PTPN14 knockdown or overexpression on proliferation, apoptosis, migration, and invasion were evaluated in\u00a0vitro using CCK\u20108, flow cytometry, wound healing, and Transwell assays. Molecular mechanisms were explored via western blotting, immunofluorescence, and rescue experiments focusing on \u03b2\u2010catenin and NF\u2010\u03baB signaling. In\u00a0vivo, a xenograft mouse model assessed tumor growth, histopathology, apoptosis (TUNEL), Ki67 expression, and serum cytokine levels (ELISA). PTPN14 was markedly upregulated in PC tissues and cell lines. Silencing PTPN14 significantly inhibited cell proliferation, migration, and invasion, while enhancing apoptosis in\u00a0vitro. Mechanistically, PTPN14 activated \u03b2\u2010catenin and NF\u2010\u03baB signaling, promoting \u03b2\u2010catenin nuclear translocation and p65 phosphorylation, with increased IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 secretion. In\u00a0vivo, PTPN14 knockdown suppressed xenograft tumor growth, reduced Ki67 expression, enhanced apoptosis, and lowered serum pro\u2010inflammatory cytokines. PTPN14 drives PC progression by co\u2010activating \u03b2\u2010catenin and NF\u2010\u03baB pathways and promoting a pro\u2010tumor inflammatory milieu. These findings highlight PTPN14 as a promising therapeutic target to inhibit PC aggressiveness and inflammation\u2010driven tumor progression.\n                  <\/jats:p>","DOI":"10.1002\/iub.70078","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:55:56Z","timestamp":1763538956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncogenic Role of\n                    <scp>PTPN14<\/scp>\n                    in Pancreatic Cancer Through \u03b2\u2010Catenin\/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway Activation"],"prefix":"10.1002","volume":"77","author":[{"given":"Danni","family":"Luo","sequence":"first","affiliation":[{"name":"The Second Clinical College of Hangzhou Normal University (Zhejiang Provincial People's Hospital)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopan","family":"Luo","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Department of Anesthesiology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"},{"name":"Research Institute of Anesthesiology and Perioperative Medicine Hangzhou Medical College  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Qian","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Department of Anesthesiology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"},{"name":"Research Institute of Anesthesiology and Perioperative Medicine Hangzhou Medical College  Hangzhou 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