{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:56:13Z","timestamp":1774569373070,"version":"3.50.1"},"reference-count":127,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["20241029Y164"],"award-info":[{"award-number":["20241029Y164"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endoplasmic reticulum glycosyltransferase ALG8 controls metabolic fate in autosomal dominant polycystic kidney disease (ADPKD). In this paper, we summarize human genetics, cell\u2010based, and organ\u2010based evidence to investigate whether ALG8 variants affect cyst initiation and metabolic states of ADPKD. Population screening showed ALG8 variant enrichment in ADPKD cohorts (OR\u2009=\u20099.75, P0.001); loss\u2010of\u2010function alleles interact with PKD1 mutations to accelerate cystogenesis. ALG8 deficiency leads to metabolic collapse by several mechanisms. Impaired polycystin\u20101 glycosylation disrupts ER\u2010to\u2010cilium trafficking, prevents PC1\/PC2 complex assembly, and impedes calcium\u2010dependent ATP production. Deficient LRP6 glycosylation activates Wnt\/\u2212catenin signaling. This shifts metabolism toward aerobic glycolysis, leading to Warburg\u2010like reprogramming seen in malignancy. Single cell analysis showed ALG8 deficient cystic epithelium has tumor\u2010like metabolic signatures, such as increased glucose uptake, suppressed oxidative phosphorylation, and glutamine dependence. Chemical chaperones that restore folding capacity or glycosylation inhibitors that lower anabolic demand both suppressed cyst formation in ALG8\/PKD1\u2010deficient organoids. The connection from ALG8 loss to \u201concogenic\u2010like\u201d metabolism remains incomplete. Study\u2010to\u2010study variability in model system, genotype, and endpoint still limits cross\u2010cohort comparison. This dual vulnerability\u2014of protein folding and glycosylation\u2014is due to the fragile metabolic balance in cystogenesis. These results recast ADPKD as a metabolic disorder where glycosylation defects link ciliary dysfunction to oncogenic transformation. We focus on three areas: (i) convergence with multiple lines of evidence, (ii) disagreement, and (iii) testable predictions for future studies and trials. The overlap between cystogenic and tumorigenic metabolic programs suggests cancer metabolic inhibitors may be reused for ADPKD in near\u2010term translation. By defining ALG8 as a metabolic checkpoint in polycystic disease, we uncover targets at the glycosylation\u2013metabolism interface.<\/jats:p>","DOI":"10.1002\/iub.70091","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:38:04Z","timestamp":1772995084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ALG8<\/scp>\n                    \u2010Driven Metabolic Reprogramming in Polycystic Kidney Disease: A Systematic Synthesis of Evidence Linking Glycosylation Defects to Metabolic Signaling"],"prefix":"10.1002","volume":"78","author":[{"given":"Xiaoran","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology The First People's Hospital of Hangzhou Lin'an District  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology Tianchang People's Hospital  Chuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-7552","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000613"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00664-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529119"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.202200037"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914666"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.06.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.01.026"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2022.0165"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.962571"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00900-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25377-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22847"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26093965"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32543-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000613"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.264133"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123377"},{"issue":"1","key":"e_1_2_11_19_1","first-page":"46","article-title":"The Role of the Polycystin\u20101\/Polycystin\u20102 Complex in Renal Mechanotransduction","volume":"18","author":"Padovano V.","year":"2022","journal-title":"Nature Reviews. Nephrology"},{"issue":"16","key":"e_1_2_11_20_1","article-title":"Polycystin\u20101 Activates the TRPC1 Cation Channel to Trigger a Calcium\u2010Dependent, Tau\u2010Mediated Cytoskeletal Collapse","volume":"119","author":"Choi H. Y.","year":"2022","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401763R"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000164"},{"issue":"14","key":"e_1_2_11_23_1","first-page":"4111","article-title":"Chemical Chaperones Assist Protein Folding and Prevent Aggregation In\u00a0Vitro and In\u00a0Vivo","volume":"45","author":"Mukherjee S.","year":"2006","journal-title":"Biochemistry"},{"issue":"1","key":"e_1_2_11_24_1","first-page":"22","article-title":"Protein N\u2010Glycosylation in the ER","volume":"1611","author":"Jarosch E.","year":"2003","journal-title":"Biochimica et Biophysica Acta"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1011051"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401763R"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.09.013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaf006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.11.016"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf158"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.04.031"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89200-z"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.01.005"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021091180"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.23.339"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027853"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-022-00309-w"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104674"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000309"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.07.006"},{"issue":"10374","key":"e_1_2_11_42_1","first-page":"385","article-title":"Autosomal Dominant Polycystic Kidney Disease: The Changing Face of Clinical Management","volume":"401","author":"Ong A. C.","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_11_43_1","first-page":"315","article-title":"Metabolic Threshold Model in ADPKD","volume":"103","author":"Schieren G.","year":"2023","journal-title":"Kidney International"},{"issue":"4","key":"e_1_2_11_44_1","first-page":"632","article-title":"Genetic Modifiers of Autosomal Dominant Polycystic Kidney Disease Progression","volume":"33","author":"Contos M. J.","year":"2022","journal-title":"Journal of the American Society of Nephrology"},{"issue":"5","key":"e_1_2_11_45_1","first-page":"1156","article-title":"Protein Quality Control and ADPKD Pathogenesis","volume":"30","author":"Cabezuelo\u2010G\u00f3mez A.","year":"2023","journal-title":"Cell Death and Differentiation"},{"issue":"18","key":"e_1_2_11_46_1","first-page":"1697","article-title":"Sirolimus and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease","volume":"379","author":"Serra A. L.","year":"2023","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"e_1_2_11_47_1","first-page":"187","article-title":"Metabolic Reprogramming in Cystogenesis","volume":"5","author":"Ebrahimi\u2010Fakhari D.","year":"2023","journal-title":"Nature Metabolism"},{"issue":"8","key":"e_1_2_11_48_1","article-title":"Membrane Trafficking and Lysosomal Dysfunction in Polycystic Kidney Disease","volume":"42","author":"Luzio J. P.","year":"2023","journal-title":"EMBO Journal"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081652"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2024.103643"},{"key":"e_1_2_11_51_1","article-title":"Kidney Measurement and Glomerular Filtration Rate Evolution in Children With Polycystic Kidney Disease","volume":"11","author":"Stroescu R.","year":"2024","journal-title":"Children (Basel)"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530657"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12508"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.11.025"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00617-7"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.022"},{"issue":"8","key":"e_1_2_11_57_1","first-page":"1152","article-title":"Autosomal Dominant Polycystic Kidney Disease in Individuals With Non\u2010Classic Presentation","volume":"17","author":"Daverman R.","year":"2022","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0250-z"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157098"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf1538"},{"issue":"4","key":"e_1_2_11_61_1","first-page":"1697","article-title":"Unfolded Protein Response in Renal Disease: Physiology and Pathology","volume":"101","author":"Carman C.","year":"2021","journal-title":"Physiological Reviews"},{"key":"e_1_2_11_62_1","volume-title":"GeneReviews","author":"Harris P. C.","year":"2023"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071822"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00547-x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.08.024"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2024.130999"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02730-w"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjac050"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111901"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14151203"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210821"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412311"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00615-8"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.49998"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13353-024-00937-1"},{"issue":"3","key":"e_1_2_11_76_1","first-page":"163","article-title":"Therapeutic Approaches Targeting Metabolic Pathways in ADPKD","volume":"19","author":"Muto S.","year":"2023","journal-title":"Nature Reviews Nephrology"},{"issue":"4","key":"e_1_2_11_77_1","article-title":"Polycystin\u20101 Function and Mitochondrial Dynamics","volume":"42","author":"Cai J.","year":"2023","journal-title":"Cell Reports"},{"issue":"4","key":"e_1_2_11_78_1","first-page":"234","article-title":"Mitochondrial Dysfunction in Kidney Disease","volume":"19","author":"Weinberg J. M.","year":"2023","journal-title":"Nature Reviews Nephrology"},{"issue":"4","key":"e_1_2_11_79_1","article-title":"Polycystin\u20101 and Its Effects on Calcium Homeostasis","volume":"22","author":"Podrini C.","year":"2021","journal-title":"EMBO Reports"},{"issue":"8","key":"e_1_2_11_80_1","article-title":"Polycystin\u2010Mediated Calcium Response in Kidney Epithelia","volume":"298","author":"Li X.","year":"2023","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"e_1_2_11_81_1","first-page":"313","article-title":"Polycystin\u2010L, a Novel Gene for Autosomal Recessive Polycystic Kidney Disease, Encodes an Integral Membrane Protein","volume":"30","author":"Bergmann C.","year":"2022","journal-title":"Nature Genetics"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308820"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.12.006"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00040.2023"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36743-2"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-024-03187-w"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2023.07.001"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2024.2433562"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.19213"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-024-00170-1"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241296270"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.07.021"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021111455"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.202300026"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2217"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261497"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022010053"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14214"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.106468"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2024.03.001"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14091755"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48025-6"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2024-0021"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.02.010"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1066504"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-024-04300-y"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107584"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100579"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000427"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113647"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2317344121"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217957"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15493"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.11.019"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04180-x"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.09.015"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00808-9"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2218616"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103486"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000326"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab131"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2024.02.016"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101283"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.16871020"},{"key":"e_1_2_11_125_1","article-title":"Associations of Skeletal Muscle Mass and Body Mass Index With Clinical Outcomes in Autosomal\u2010Dominant Polycystic Kidney Disease: An Observational Study","author":"Im D. W.","year":"2025","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000943"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-024-02446-4"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.12.006"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:20:54Z","timestamp":1774567254000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/iub.70091"],"URL":"https:\/\/doi.org\/10.1002\/iub.70091","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70091"}}