{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:39:58Z","timestamp":1790138398732,"version":"4.0.1"},"reference-count":94,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["528455242"],"award-info":[{"award-number":["528455242"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>CYP17A1<\/jats:italic>\n                    gene encodes the P450 17\u03b1\u2010hydroxylase\/17,20\u2010lyase protein, a key enzyme in steroidogenesis. In the past, it was associated with disorders such as congenital adrenal hyperplasia, disorders of sex development, and castration resistant prostate cancer. Recently, genome\u2010wide association studies have revealed that the locus harboring the\n                    <jats:italic>CYP17A1<\/jats:italic>\n                    gene is strongly associated with multiple other traits, including cardiovascular and metabolic characteristics. This review summarizes the current knowledge about the regulatory mechanisms and monogenic disease implications of the\n                    <jats:italic>CYP17A1<\/jats:italic>\n                    gene, then attempts to link the locus to cardiovascular and metabolic diseases, using experimental evidence supporting these relationships. Additionally, the review also speculates that the research focus may have been placed solely on one gene of the locus, which could have obscured the effects of other neighboring ones. In summary, our review aimed to highlight this locus as a complex regulatory region with implications that extend beyond a single gene.\n                  <\/jats:p>","DOI":"10.1002\/iub.70096","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:45:59Z","timestamp":1775209559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>CYP17A1<\/i>\n                    <\/scp>\n                    Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1423-4143","authenticated-orcid":false,"given":"Yasmine","family":"Chakkor","sequence":"first","affiliation":[{"name":"Institute for Cardiogenetics, University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redouane","family":"Aherrahrou","sequence":"additional","affiliation":[{"name":"Institute for Cardiogenetics, University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck  L\u00fcbeck Germany"},{"name":"University Heart Centre L\u00fcbeck  L\u00fcbeck Germany"},{"name":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland  Kuopio Finland"},{"name":"Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01233-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01714-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14177"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07019-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.048"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.12.007"},{"issue":"7","key":"e_1_2_11_8_1","first-page":"1467","article-title":"Decoding the Role of CYP450 Enzymes in Metabolism and Disease: A Comprehensive Review","volume":"12","author":"Hossam Abdelmonem B.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.05.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-03962-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.02.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20940"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.001180"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141634"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07848"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13138"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502214"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae773"},{"key":"e_1_2_11_19_1","unstructured":"An Overview|ScienceDirect \u201cDisorders of Sex Development\u2014An Overview|ScienceDirect Topics [Internet] \u201dhttps:\/\/www.sciencedirect.com\/topics\/pharmacology\u2010toxicology\u2010and\u2010pharmaceutical\u2010science\/disorders\u2010of\u2010sex\u2010development?utm_source=chatgpt.com."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-024-03366-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.103855"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luae100"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-01737-1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113521"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80140-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1987.6.439"},{"issue":"8","key":"e_1_2_11_27_1","first-page":"1277","article-title":"NF\u20101C, Sp1, and Sp3 Are Essential for Transcription of the Human Gene for P450c17 (Steroid 17alpha\u2010Hydroxylase\/17,20 Lyase) in Human Adrenal NCI\u2010H295A Cells","volume":"15","author":"Lin C. 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