{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:46:27Z","timestamp":1791949587772,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u2010RS\u20102024\u201000353119"],"award-info":[{"award-number":["NRF\u2010RS\u20102024\u201000353119"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Receptor for advanced glycation end\u2010products (RAGE) was originally identified as a receptor for advanced glycation end\u2010products; however, it can also bind a broader range of damage\u2010associated molecular patterns, including S100 proteins, high mobility group box\u00a01, and amyloid\u2010\u03b2. Ligand\u2010induced RAGE activation promotes receptor oligomerization and recruitment of diaphanous\u2010related formin\u20101, which activates several intracellular cascades, leading to the production of inflammatory mediators and reactive oxygen species. RAGE expression is upregulated in disease\u2010associated tissues, including adipose tissue in diabetes and microglia and neurons in Alzheimer's disease, and the mechanisms by which RAGE activation contributes to pathogenesis are disease\u2010specific. The review summarizes the expression and activation of RAGE, and the potential mechanisms through which RAGE contributes to disease pathogenesis. We further discuss current and emerging strategies for modulating RAGE signaling and highlight their therapeutic potential in the prevention and treatment of RAGE\u2010associated diseases.<\/jats:p>","DOI":"10.1002\/iub.70137","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:11:27Z","timestamp":1791947487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Receptor for Advanced Glycation End Products: Regulation and Implications in Metabolic Diseases"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-0671","authenticated-orcid":false,"given":"Ga Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition College of Human Ecology, Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-2992","authenticated-orcid":false,"given":"Sung Nim","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition College of Human Ecology, Seoul National University  Seoul Korea"},{"name":"Human Ecology Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"14998","DOI":"10.1016\/S0021-9258(18)42138-2","article-title":"Cloning and Expression of a Cell Surface Receptor for Advanced Glycosylation End Products of Proteins","volume":"267","author":"Neeper M.","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.931473","article-title":"Pathophysiology of RAGE in Inflammatory Diseases","volume":"13","author":"Dong H.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"34457","DOI":"10.1074\/jbc.M801465200","article-title":"Interaction of the RAGE Cytoplasmic Domain With Diaphanous\u20101 Is Required for Ligand\u2010Stimulated Cellular Migration Through Activation of Rac1 and Cdc42","volume":"283","author":"Hudson B. I.","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cellsig.2013.06.013","article-title":"Cellular Signalling of the Receptor for Advanced Glycation End Products (RAGE)","volume":"25","author":"Xie J.","year":"2013","journal-title":"Cellular Signalling"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/biom14040412","article-title":"The RAGE Axis: A Relevant Inflammatory Hub in Human Diseases","volume":"14","author":"Rojas A.","year":"2024","journal-title":"Biomolecules"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.3390\/ijms22136904","article-title":"Molecular Characteristics of RAGE and Advances in Small\u2010Molecule Inhibitors","volume":"22","author":"Kim H. J.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1042\/bj20021371","article-title":"Novel Splice Variants of the Receptor for Advanced Glycation End\u2010Products Expressed in Human Vascular Endothelial Cells and Pericytes, and Their Putative Roles in Diabetes\u2010Induced Vascular Injury","volume":"370","author":"Yonekura H.","year":"2003","journal-title":"Biochemical Journal"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1111\/febs.12556","article-title":"Structural Insights Into the Oligomerization Mode of the Human Receptor for Advanced Glycation End\u2010Products","volume":"280","author":"Yatime L.","year":"2013","journal-title":"FEBS Journal"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"101958","DOI":"10.1016\/j.redox.2021.101958","article-title":"The Use of the Soluble Receptor for Advanced Glycation\u2010End Products (sRAGE) as a Potential Biomarker of Disease Risk and Adverse Outcomes","volume":"42","author":"Erusalimsky J. D.","year":"2021","journal-title":"Redox Biology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1096\/fj.08-109033","article-title":"A Soluble Form of the Receptor for Advanced Glycation Endproducts (RAGE) is Produced by Proteolytic Cleavage of the Membrane\u2010Bound Form by the Sheddase a Disintegrin and Metalloprotease 10 (ADAM10)","volume":"22","author":"Raucci A.","year":"2008","journal-title":"FASEB Journal"},{"key":"e_1_2_11_12_1","first-page":"1699","article-title":"Survey of the Distribution of a Newly Characterized Receptor for Advanced Glycation End Products in Tissues","volume":"143","author":"Brett J.","year":"1993","journal-title":"American Journal of Pathology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"175346662110160","DOI":"10.1177\/17534666211016071","article-title":"The Perplexing Role of RAGE in Pulmonary Fibrosis: Causality or Casualty?","volume":"15","author":"Perkins T. N.","year":"2021","journal-title":"Therapeutic Advances in Respiratory Disease"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/S146239940900101X","article-title":"The Receptor for Advanced Glycation Endproducts (RAGE) and Cardiovascular Disease","volume":"11","author":"Yan S. F.","year":"2009","journal-title":"Expert Reviews in Molecular Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/21623945.2020.1817278","article-title":"RAGE Signalling in Obesity and Diabetes: Focus on the Adipose Tissue Macrophage","volume":"9","author":"Feng Z.","year":"2020","journal-title":"Adipocyte"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3389\/fimmu.2020.01157","article-title":"The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice","volume":"11","author":"Weinhage T.","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tem.2009.07.003","article-title":"RAGE, Glomerulosclerosis and Proteinuria: Roles in Podocytes and Endothelial Cells","volume":"21","author":"D'Agati V.","year":"2010","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41419-022-04856-z","article-title":"Proximal Tubular RAGE Mediated the Renal Fibrosis in UUO Model Mice via Upregulation of Autophagy","volume":"13","author":"Liu B.","year":"2022","journal-title":"Cell Death & Disease"},{"key":"e_1_2_11_19_1","first-page":"813","article-title":"RAGE Ligands Induce Apoptotic Cell Death of Pancreatic \u03b2\u2010Cells via Oxidative Stress","volume":"26","author":"Lee B. W.","year":"2010","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1038\/s41598-023-39243-x","article-title":"Alpha Cell Receptor for Advanced Glycation End Products Associate With Glucagon Expression in Type 1 Diabetes","volume":"13","author":"Leung S. S.","year":"2023","journal-title":"Scientific Reports"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","article-title":"Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives","volume":"12","author":"Khalid M.","year":"2022","journal-title":"Biomolecules"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"25752","DOI":"10.1074\/jbc.270.43.25752","article-title":"The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin. Mediation of Neurite Outgrowth and Co\u2010Expression of Rage and Amphoterin in the Developing Nervous System","volume":"270","author":"Hori O.","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","article-title":"RAGE Mediates a Novel Proinflammatory Axis: A Central Cell Surface Receptor for S100\/Calgranulin Polypeptides","volume":"97","author":"Hofmann M. A.","year":"1999","journal-title":"Cell"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/ATVBAHA.110.217745","article-title":"S100A12 in Vascular Smooth Muscle Accelerates Vascular Calcification in Apolipoprotein E\u2010Null Mice by Activating an Osteogenic Gene Regulatory Program","volume":"31","author":"Hofmann Bowman M. A.","year":"2011","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/382685a0","article-title":"RAGE and Amyloid\u2010Beta Peptide Neurotoxicity in Alzheimer's Disease","volume":"382","author":"Yan S. D.","year":"1996","journal-title":"Nature"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.chembiol.2025.09.004","article-title":"RAGE\u2010Mediated Activation of the Formin DIAPH1 and Human Macrophage Inflammation Are Inhibited by a Small Molecule Antagonist","volume":"32","author":"Theophall G. G.","year":"2025","journal-title":"Cell Chemical Biology"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"e23132","DOI":"10.1371\/journal.pone.0023132","article-title":"TIRAP, an Adaptor Protein for TLR2\/4, Transduces a Signal From RAGE Phosphorylated Upon Ligand Binding","volume":"6","author":"Sakaguchi M.","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1038\/s41467-023-42521-x","article-title":"DIAPH1\u2013MFN2 Interaction Regulates Mitochondria\u2010SR\/ER Contact and Modulates Ischemic\/Hypoxic Stress","volume":"14","author":"Yepuri G.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1161\/ATVBAHA.124.320142","article-title":"RAGE\/DIAPH1 Axis and Cardiometabolic Disease: From Nascent Discoveries to Therapeutic Potential","volume":"44","author":"Ramasamy R.","year":"2024","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"1062229","DOI":"10.3389\/fcell.2023.1062229","article-title":"Advanced Glycation End Products Regulate the Receptor of AGEs Epigenetically","volume":"11","author":"Wu X.","year":"2023","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","article-title":"Receptor for AGE (RAGE): Signaling Mechanisms in the Pathogenesis of Diabetes and Its Complications","volume":"1243","author":"Ramasamy R.","year":"2011","journal-title":"Annals of the New York Academy of Sciences"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"110037","DOI":"10.1016\/j.jnutbio.2025.110037","article-title":"Vitamin D(3) Supplementation Ameliorates Adipose Tissue Inflammation and Adipocyte Hypertrophy in Type 2 Diabetic Mice Through Downregulation of RAGE and SREBP\u20101c","volume":"145","author":"Kim Y. A.","year":"2025","journal-title":"Journal of Nutritional Biochemistry"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00414-016-1529-7","article-title":"Detection of RAGE Expression and Its Application to Diabetic Wound Age Estimation","volume":"131","author":"Ji X. Y.","year":"2017","journal-title":"International Journal of Legal Medicine"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.arcmed.2011.11.001","article-title":"Elevated Serum Levels of Advanced Glycation End Products and Their Monocyte Receptors in Patients With Type 2 Diabetes","volume":"42","author":"Su X. D.","year":"2011","journal-title":"Archives of Medical Research"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.2337\/db15-0575","article-title":"RAGE Suppresses ABCG1\u2010Mediated Macrophage Cholesterol Efflux in Diabetes","volume":"64","author":"Daffu G.","year":"2015","journal-title":"Diabetes"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"23072","DOI":"10.18632\/oncotarget.8604","article-title":"The Pathological Role of Advanced Glycation End Products\u2010Downregulated Heat Shock Protein 60 in Islet \u03b2\u2010Cell Hypertrophy and Dysfunction","volume":"7","author":"Guan S. S.","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/01.ATV.0000133191.71196.90","article-title":"RAGE Axis: Animal Models and Novel Insights Into the Vascular Complications of Diabetes","volume":"24","author":"Naka Y.","year":"2004","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced Glycation End Products","volume":"114","author":"Goldin A.","year":"2006","journal-title":"Circulation"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"e23259","DOI":"10.1096\/fj.202300173RR","article-title":"Macrophage RAGE Deficiency Prevents Myocardial Fibrosis by Repressing Autophagy\u2010Mediated Macrophage Alternative Activation","volume":"37","author":"He J.","year":"2023","journal-title":"FASEB Journal"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"1155175","DOI":"10.3389\/fnmol.2023.1155175","article-title":"AGE\u2010RAGE Axis Culminates Into Multiple Pathogenic Processes: A Central Road to Neurodegeneration","volume":"16","author":"Bhattacharya R.","year":"2023","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nm890","article-title":"RAGE Mediates Amyloid\u2010Beta Peptide Transport Across the Blood\u2010Brain Barrier and Accumulation in Brain","volume":"9","author":"Deane R.","year":"2003","journal-title":"Nature Medicine"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/pathophysiology32030043","article-title":"Current Evidence on the Involvement of RAGE\u2010Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases\u2010An Overview","volume":"32","author":"Juranek J. K.","year":"2025","journal-title":"Pathophysiology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.prrv.2017.03.012","article-title":"All the \u201cRAGE\u201d in Lung Disease: The Receptor for Advanced Glycation Endproducts (RAGE) is a Major Mediator of Pulmonary Inflammatory Responses","volume":"23","author":"Oczypok E. A.","year":"2017","journal-title":"Paediatric Respiratory Reviews"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"L641","DOI":"10.1152\/ajplung.00138.2021","article-title":"LL\u201037 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE","volume":"321","author":"Pouwels S. D.","year":"2021","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","article-title":"Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet","volume":"110","author":"Uribarri J.","year":"2010","journal-title":"Journal of the American Dietetic Association"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"1737974","DOI":"10.3389\/fnut.2026.1737974","article-title":"Dietary Advanced Glycation End Products (AGEs) and Type 2 Diabetes (T2D): A Case\u2013Control Study","volume":"13","author":"Salman Alharbi S.","year":"2026","journal-title":"Frontiers in Nutrition"},{"key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/advances\/nmaa150","article-title":"The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk Factors: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"12","author":"Sohouli M. H.","year":"2021","journal-title":"Advances in Nutrition"},{"key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1038\/s41598-017-04214-6","article-title":"Effect of Dietary Advanced Glycation End Products on Inflammation and Cardiovascular Risks in Healthy Overweight Adults: A Randomised Crossover Trial","volume":"7","author":"Baye E.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"15888","DOI":"10.1073\/pnas.1205847109","article-title":"Oral Advanced Glycation Endproducts (AGEs) Promote Insulin Resistance and Diabetes by Depleting the Antioxidant Defenses AGE Receptor\u20101 and Sirtuin 1","volume":"109","author":"Cai W.","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.clnu.2017.03.019","article-title":"Dietary Intake of Advanced Glycation Endproducts Is Associated With Higher Levels of Advanced Glycation Endproducts in Plasma and Urine: The CODAM Study","volume":"37","author":"Scheijen J.","year":"2018","journal-title":"Clinical Nutrition"},{"key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ejcn.2011.139","article-title":"Dietary Intake Associated With Serum Versus Urinary Carboxymethyl\u2010Lysine, a Major Advanced Glycation End Product, in Adults: The Energetics Study","volume":"66","author":"Semba R. D.","year":"2012","journal-title":"European Journal of Clinical Nutrition"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"112987","DOI":"10.1016\/j.fct.2022.112987","article-title":"Differences in Kinetics and Dynamics of Endogenous Versus Exogenous Advanced Glycation End Products (AGEs) and Their Precursors","volume":"164","author":"Dongen K. C. W.","year":"2022","journal-title":"Food and Chemical Toxicology"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.numecd.2023.05.022","article-title":"Correlation Between Serum Advanced Glycation End Products and Dietary Intake of Advanced Glycation End Products Estimated From Home Cooking and Food Frequency Questionnaires","volume":"33","author":"Vasilj M.","year":"2023","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"e0189707","DOI":"10.1371\/journal.pone.0189707","article-title":"Effects of Vitamin D on Insulin Resistance and Myosteatosis in Diet\u2010Induced Obese Mice","volume":"13","author":"Benetti E.","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"21352","DOI":"10.1002\/jcp.28743","article-title":"Vitamin D Downregulates Key Genes of Diabetes Complications in Cardiomyocyte","volume":"234","author":"Derakhshanian H.","year":"2019","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_11_56_1","first-page":"217","article-title":"The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy","volume":"7","author":"Derakhshanian H.","year":"2019","journal-title":"Reports of Biochemistry and Molecular Biology"},{"key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41420-025-02898-8","article-title":"Glutamine: Fructose\u20106\u2010Phosphate Amidotransferase (GFAT) in the Pathology of Diseases: A Review","volume":"12","author":"Yang C.","year":"2025","journal-title":"Cell Death Discovery"},{"key":"e_1_2_11_58_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuroscience.2016.01.041","article-title":"1,25\u2010Dihydroxyvitamin D3 Regulates Expression of LRP1 and RAGE In\u00a0Vitro and In\u00a0Vivo, Enhancing A\u03b21\u201040 Brain\u2010to\u2010Blood Efflux and Peripheral Uptake Transport","volume":"322","author":"Guo Y. X.","year":"2016","journal-title":"Neuroscience"},{"key":"e_1_2_11_59_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1620\/tjem.230.59","article-title":"Calcitriol Treatment Increases Serum Levels of the Soluble Receptor of Advanced Glycation End Products in Hemodialysis Patients With Secondary Hyperparathyroidism","volume":"230","author":"Sung J. Y.","year":"2013","journal-title":"Tohoku Journal of Experimental Medicine"},{"key":"e_1_2_11_60_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13098-019-0479-x","article-title":"Effects of Vitamin D Supplementation on Advanced Glycation End Products Signaling Pathway in T2DM Patients: A Randomized, Placebo\u2010Controlled, Double Blind Clinical Trial","volume":"11","author":"Omidian M.","year":"2019","journal-title":"Diabetology and Metabolic Syndrome"},{"key":"e_1_2_11_61_1","doi-asserted-by":"crossref","first-page":"7213","DOI":"10.1021\/acs.jmedchem.7b00058","article-title":"Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective","volume":"60","author":"Bongarzone S.","year":"2017","journal-title":"Journal of Medicinal Chemistry"},{"key":"e_1_2_11_62_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41523-023-00564-9","article-title":"RAGE Inhibitor TTP488 (Azeliragon) Suppresses Metastasis in Triple\u2010Negative Breast Cancer","volume":"9","author":"Magna M.","year":"2023","journal-title":"NPJ Breast Cancer"},{"key":"e_1_2_11_63_1","doi-asserted-by":"crossref","first-page":"22450","DOI":"10.1038\/srep22450","article-title":"Small Molecule Inhibition of Ligand\u2010Stimulated RAGE\u2013DIAPH1 Signal Transduction","volume":"6","author":"Manigrasso M. B.","year":"2016","journal-title":"Scientific Reports"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.70137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.70137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.70137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:11:40Z","timestamp":1791947500000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.70137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/iub.70137"],"URL":"https:\/\/doi.org\/10.1002\/iub.70137","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70137"}}