{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:47:50Z","timestamp":1791780470406,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriatic lesions contain sustained inflammatory stress, but whether death\u2010associated tissue activity is matched by adequate clearance capacity remains poorly defined. To address this, spatial transcriptomics was used to define clearance imbalance in psoriatic skin, with peripheral CITE\u2010seq assessing circulating myeloid clearance states. Within leucocyte\u2010rich tissue regions, stress\u2010death and clearance\u2010capacity modules identified clearance\u2010competent niches, marked by matched stress and clearance activity and clearance\u2010defective niches, marked by stress\u2010death activity without comparable clearance capacity. This revealed that lesional psoriatic skin shows a selective epidermal clearance imbalance, with increased clearance defect, a higher defective\u2010to\u2010competent niche ratio and distinct clearance\u2010defective transcriptional programming enriched for stress\u2010processing and stress\u2010response pathways. The clinical relevance of this epidermal axis was supported by a correlation between epidermal, but not dermal, clearance defect and psoriasis severity. Within this severity\u2010linked compartment, a preserved monocyte\/macrophage\u2010rich burden masked reduced clearance\u2010associated programming, indicating that defective epidermal niches retain myeloid\u2010rich spatial contexts without matched clearance capacity. Peripheral profiling extended this axis to circulation, where psoriatic arthritis showed increased clearance defect scores in mononuclear myeloid cells and a clearance\u2010defective surface phenotype linked to reduced efferocytosis\u2010associated capacity. Together, these findings define clearance\u2010defective psoriatic inflammation as an epidermal tissue programme with convergent circulating myeloid clearance defects in higher burden disease.<\/jats:p>","DOI":"10.1002\/iub.70138","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:38:31Z","timestamp":1791779911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial Transcriptomic and\n                    <scp>CITE<\/scp>\n                    \u2010Seq Analyses Identify Clearance\u2010Defective Signatures in Psoriatic Disease"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1168-8392","authenticated-orcid":false,"given":"Caio Santos","family":"Bonilha","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong A. 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