{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:11:19Z","timestamp":1769098279133,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Variations within the catechol\u2010O<\/jats:styled-content>\u2010methyltransferase<\/jats:italic> (COMT<\/jats:styled-content><\/jats:italic>) gene have been associated with pain severity in temporomandibular disorders (TMDs<\/jats:styled-content>). Psychological factors such as personal conflicts, life stress and depression, are well known to be associated with onset, severity and chronicity of pain disorders.<\/jats:p><\/jats:sec>Aim<\/jats:title>We hypothesized that the relationship between the COMT<\/jats:styled-content><\/jats:italic> gene and TMD<\/jats:styled-content> pain is modified by depressive symptoms.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cross\u2010sectional data from the population\u2010based Study of Health in Pomerania (SHIP) in G<\/jats:styled-content>ermany were used to estimate additive interactions between depressive symptoms and 22 single\u2010nucleotide polymorphisms (SNPs<\/jats:styled-content>) of the COMT<\/jats:styled-content><\/jats:italic> gene and the neighbouring thioredoxin reductase 2<\/jats:italic> (TXNRD2<\/jats:italic>) gene on TMD<\/jats:styled-content> pain. All participants were Caucasian subjects from a rural area in Northeast G<\/jats:styled-content>ermany. After exclusion of 79 subjects with antidepressant medication, 29.9% of the remaining 3904 subjects reported lifetime depressive symptoms. TMD<\/jats:styled-content> pain was assessed by a standardized clinical examination. Among various TMD<\/jats:styled-content> signs, only those that assessed muscle or joint pain on palpation were used as recommended.<\/jats:p><\/jats:sec>Results<\/jats:title>Six SNPs<\/jats:styled-content> from the first of three COMT<\/jats:styled-content><\/jats:italic>\/TXNRD2<\/jats:italic> haploblocks interacted with depressive symptoms on TMD<\/jats:styled-content> pain (smallest p<\/jats:italic>\u2010value: 2.7\u2009\u00d7\u200910\u221210<\/jats:sup>). In subjects without depressive symptoms, rs5993882 was identified as the SNP<\/jats:styled-content> most likely to be related to TMD<\/jats:styled-content> pain. In subjects with symptoms of depression, rs1544325 was the corresponding top COMT<\/jats:styled-content><\/jats:italic> SNP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our results indicate that variants within the COMT<\/jats:styled-content><\/jats:italic> gene are associated with pain perception. However, this association is highly moderated by the absence or presence of lifetime depressive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2011.00067.x","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T11:42:19Z","timestamp":1324554139000},"page":"878-889","source":"Crossref","is-referenced-by-count":15,"title":["The effect of catechol\u2010O<\/scp>\u2010methyltransferase<\/i> polymorphisms on pain is modified by depressive symptoms"],"prefix":"10.1002","volume":"16","author":[{"given":"C.","family":"Schwahn","sequence":"first","affiliation":[{"name":"Unit of Oral and Systemic Diseases Department of Prosthodontics, Gerodontology and Dental Materials Center of Oral Health University of Greifswald Greifswald Germany"},{"name":"Department of Mathematics and Computer Science University of Greifswald Greifswald Germany"},{"name":"Institute of Clinical Chemistry and Laboratory Medicine University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Grabe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Meyer zu","family":"Schwabedissen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Center for Pharmacology and Experimental Therapeutics University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Teumer","sequence":"additional","affiliation":[{"name":"Interfacultary Institute for Genetics and Functional Genomics University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.O.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Unit of Oral and Systemic Diseases Department of Prosthodontics, Gerodontology and Dental Materials Center of Oral Health University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kocher","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology and Endodontology Center of Oral Health University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nauck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Biffar","sequence":"additional","affiliation":[{"name":"Unit of Oral and Systemic Diseases Department of Prosthodontics, Gerodontology and Dental Materials Center of Oral Health University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology and Endodontology Center of Oral Health University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.09.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.11.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301462"},{"key":"e_1_2_6_7_1","first-page":"55","article-title":"Risk factors for headache, including TMD signs and symptoms, and their impact on quality of life. Results of the Study of Health in Pomerania (SHIP)","volume":"36","author":"Bernhardt O","year":"2005","journal-title":"Quintessence Int"},{"key":"e_1_2_6_8_1","first-page":"29","article-title":"Reliability and validity of a new fingertip\u2010shaped pressure algometer for assessing pressure pain thresholds in the temporomandibular joint and masticatory muscles","volume":"21","author":"Bernhardt O","year":"2007","journal-title":"J Orofac Pain"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1331.2001.00727.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2010.519762"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720110901"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.05.024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2008.09.019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03057-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.12.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199706000-00006"},{"key":"e_1_2_6_18_1","volume-title":"Clinical epidemiology: the essentials","author":"Fletcher RH","year":"2005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-009-0005-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08101542"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068681"},{"key":"e_1_2_6_22_1","first-page":"370","article-title":"Study of Health in Pomerania (SHIP): a health survey in an East German region. Objectives and design of the oral health section","volume":"34","author":"Hensel E","year":"2003","journal-title":"Quintessence Int"},{"key":"e_1_2_6_23_1","first-page":"Doc03","article-title":"Prevalence of somatoform pain complaints in the German population","volume":"2","author":"Hessel A","year":"2005","journal-title":"Psychosoc Med"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.01.023"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01854.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0043"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00404-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01324255"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.04.005"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2010.05.013"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.04.001"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.02.011"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym157"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.06.001"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.10.012"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31815b0103"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02121.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20140"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2006"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.64"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005237"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131262"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126086"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/383251"},{"key":"e_1_2_6_45_1","first-page":"23","volume-title":"Orofacial pain: Guidelines for assessment, diagnosis, and management","author":"Okeson JP","year":"1996"},{"key":"e_1_2_6_46_1","volume-title":"Epidemiology: an introduction","author":"Rothman KJ","year":"2002"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470061596.risk0599"},{"key":"e_1_2_6_48_1","first-page":"128","volume-title":"Modern epidemiology","author":"Rothman KJ","year":"2008"},{"key":"e_1_2_6_49_1","first-page":"5","volume-title":"Modern epidemiology","author":"Rothman KJ","year":"2008"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.04.022"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1577"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0802472"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20358"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601119"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.57"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32832c15c6"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1532-2149.2011.00067.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1532-2149.2011.00067.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T18:30:07Z","timestamp":1697481007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/j.1532-2149.2011.00067.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/j.1532-2149.2011.00067.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1532-2149.2011.00067.x","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,19]]}}}