{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T22:43:10Z","timestamp":1776638590933,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The COMT<\/jats:styled-content> enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP<\/jats:styled-content> that reduces enzyme activity, has previously been linked to pain sensitivity.<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined if the COMT Val158Met SNP<\/jats:styled-content> could contribute to discogenic subacute low back pain and sciatica by comparing the frequency of the Val158Met<\/jats:styled-content> genotypes of degenerative disc disease patients with healthy controls. Moreover, we examined if this SNP<\/jats:styled-content> could predict the clinical outcome, i.e. the progression of pain and disability.<\/jats:p><\/jats:sec>Results<\/jats:title>The present data demonstrated that there were no differences in COMT<\/jats:styled-content> genotype frequencies between the newly diagnosed patients and controls. Analysis of pain and disability in the patients over time revealed, however, a significant or border\u2010line significant increase in McGill<\/jats:styled-content> sensory score and O<\/jats:styled-content>swestry D<\/jats:styled-content>isability I<\/jats:styled-content>ndex (ODI<\/jats:styled-content>) score for individuals with COMT Met\/Met<\/jats:styled-content> genotype. Furthermore, significant associations between the COMT<\/jats:styled-content> Met\u2010allele and VAS<\/jats:styled-content> activity score, McGill<\/jats:styled-content> sensory score and ODI<\/jats:styled-content> score were observed in the patients 6 months after inclusion.<\/jats:p><\/jats:sec>Discussion<\/jats:title>Although the Val158Met SNP<\/jats:styled-content> was not a risk factor for disc herniation, patients with Met\/Met<\/jats:styled-content> had more pain and slower recovery than those with Val\/Met<\/jats:styled-content>, which in turn also had more pain and slower recovery than those with Val\/Val<\/jats:styled-content> suggesting the SNP<\/jats:styled-content> contributes to the progression of the symptoms of disc herniation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We conclude that the functional COMT Val158Met SNP<\/jats:styled-content> contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2011.00102.x","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T08:53:10Z","timestamp":1327049590000},"page":"1064-1069","source":"Crossref","is-referenced-by-count":51,"title":["The COMT rs<\/scp>4680 M<\/scp>et allele contributes to long\u2010lasting low back pain, sciatica and disability after lumbar disc herniation"],"prefix":"10.1002","volume":"16","author":[{"given":"L.M.","family":"Jacobsen","sequence":"first","affiliation":[{"name":"National Institute of Occupational Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.I.","family":"Schistad","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Oslo University Hospital Ullev\u00e5l Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Storesund","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health Oslo Norway"},{"name":"Department of Physical Medicine and Rehabilitation Oslo University Hospital Ullev\u00e5l Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.J.","family":"Rygh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"R\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Oslo University Hospital Ullev\u00e5l Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gjerstad","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health Oslo Norway"},{"name":"Department of Molecular Biosciences University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-8-48"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1097\/00007632-199512150-00001","article-title":"1995 Volvo Award in clinical sciences. 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