{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:26:18Z","timestamp":1774326378921,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Neuropathic pain after nerve injury is severe and intractable, and current drug and non\u2010drug therapies offer very limited pain relief. Hyperbaric oxygen (<jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content>) has been clinically used for protection of the nervous system after acute injury. We investigated whether <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> treatment could prevent and\/or attenuate neuropathic pain in animals and in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Mechanical allodynia and thermal hyperalgesia and neurochemical alterations of neuropathic pain were analysed in male, adult, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats with sciatic nerve injury. Clinical trials were conducted in patients with idiopathic trigeminal neuralgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Repetitive <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> treatment [a combination of pressure at 3 atmosphere absolute (<jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content>) and pure oxygen] greatly inhibited behavioural signs of neuropathic pain manifested as thermal hyperalgesia and mechanical allodynia. Such an <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> treatment also inhibited nerve injury\u2010induced induction of c\u2010<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>os and activation of astrocytes and increased phosphorylation of <jats:styled-content style=\"fixed-case\">NR2B<\/jats:styled-content> receptor and the subsequent <jats:styled-content style=\"fixed-case\"><jats:roman>Ca<\/jats:roman>\n<jats:sup>2+<\/jats:sup><\/jats:styled-content>\u2010dependent signals in rats. Neither high pressure (up to 3 <jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content>) nor pure oxygen alone resulted in analgesic effect. In clinical trials, one course of <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> therapy (10 consecutive days) produced a rapid\u2010onset, dose\u2010dependent and long\u2010lasting analgesic effects evidenced by the decreased doses of carbamazepine required for keeping patient pain at a minimum and decreased scores of visual analogue scales, which was used for patient's self\u2010evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>These findings support that <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> therapy is an effective approach for treating neuropathic pain in both animals and human beings and suggest that neural protection, anti\u2010inflammation and inhibition of nerve injury\u2010induced altered neural activity may contribute to the analgesic effect of <jats:styled-content style=\"fixed-case\"><jats:roman>HBO<\/jats:roman>\n<jats:sub>2<\/jats:sub><\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2012.00113.x","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T17:20:30Z","timestamp":1329844830000},"page":"1094-1105","source":"Crossref","is-referenced-by-count":45,"title":["Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients"],"prefix":"10.1002","volume":"16","author":[{"given":"N.","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Xijing Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010Y.","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xijing Hospital The Fourth Military Medical University  Xi'an 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