{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:28:14Z","timestamp":1761488894258},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:00:00Z","timestamp":1332979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral nerve injury is associated with a spinal microglial response that has been correlated with the development of behaviours reflective of neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To examine whether this phenomenon is generalizable to neuropathic pain of non\u2010traumatic aetiology, this study investigated the association between spinal microgliosis and behavioural measures of neuropathic hypersensitivity and pain\u2010related anxiety behaviour in four distinct rat models of peripheral neuropathic pain. These were traumatic neuropathy [<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>5 spinal nerve transection (<jats:styled-content style=\"fixed-case\">SNT<\/jats:styled-content>)], <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related neuropathies (either treatment with the antiretroviral drug <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>alcitabine (dd<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) or combination of perineural exposure to the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010gp120 protein and dd<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> treatment) and varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Persistent mechanical hypersensitivity developed in all \u2018neuropathic\u2019 rats. However, spinal microgliosis, as measured by increased <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b\/c immunohistochemical staining and increased numbers of cells expressing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b measured by flow cytometry, was evident in the <jats:styled-content style=\"fixed-case\">SNT<\/jats:styled-content> and to a lesser extent in the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> neuropathy models but not the <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> model. These results suggest that behavioural hypersensitivity and thigmotaxis can only be linked to a microglial response in certain models of neuropathy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2012.00140.x","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T23:37:22Z","timestamp":1333409842000},"page":"1357-1367","source":"Crossref","is-referenced-by-count":26,"title":["The correlation between pain\u2010related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy"],"prefix":"10.1002","volume":"16","author":[{"given":"J.","family":"Blackbeard","sequence":"first","affiliation":[{"name":"Section of Anaesthetics, Pain Medicine and Intensive Care Department of Surgery and Cancer Imperial College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.C.J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Section of Anaesthetics, Pain Medicine and Intensive Care Department of 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