{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T14:28:56Z","timestamp":1746196136631},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension has been associated with hypoalgesia. This prospective study was designed to test the effects of untreated preoperative essential hypertension on post\u2010operative pain intensity and morphine requirement after major abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty subjects (30 untreated essential hypertensives and 30 normotensives) scheduled for abdominal surgery were included in this study. All subjects received standardized anaesthetic with intra\u2010operative fentanyl and patient\u2010controlled analgesia with morphine for 48\u2009h post\u2010operatively as the only analgesics. Pain intensity scores, cumulative morphine requirement and side effects were recorded until 48\u2009h post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects with essential hypertension had systolic hypertension, 93.3% had grade 1 severity and 6.7% had grade 2 severity. 23.3% of essential hypertensive subjects had elevated diastolic blood pressure. Essential hypertensive subjects had significantly lower total post\u2010operative morphine requirement (29.6\u2009mg vs. 49.9\u2009mg; <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\u2009=\u20090.002), significantly lower verbal rating scale post\u2010operative pain intensity scores at rest and with coughing (<jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\u2009=\u20090.000), and significantly less incidence of post\u2010operative pruritus (<jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\u2009=\u20090.048) over 48\u2009h than normotensive subjects. There were no post\u2010operative differences in the incidence of post\u2010operative nausea (<jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\u2009=\u20090.982) or vomiting (<jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\u2009=\u20090.644) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Untreated essential hypertension is associated with significantly reduced post\u2010operative morphine requirement and pain intensity, suggesting hypertension\u2010associated hypoalgesia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2012.00156.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T14:07:55Z","timestamp":1335276475000},"page":"94-100","source":"Crossref","is-referenced-by-count":8,"title":["Effects of untreated preoperative essential hypertension on post\u2010operative pain after major abdominal 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