{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:36:11Z","timestamp":1789731371532,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropathy can lead not only to impaired function but also to sensory sensitization. We aimed to link reduced skin nerve fibre density in different levels to layer\u2010specific functional impairment in neuropathic pain patients and tried to identify pain\u2010specific functional and structural markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 12 healthy controls and 36 patients with neuropathic pain, we assessed clinical characteristics, thermal thresholds (quantitative sensory testing) and electrically induced pain and axon reflex erythema. At the most painful sites and at intra\u2010individual control sites, skin biopsies were taken and innervation densities in the different skin layers were assessed. Moreover, neuronal calcitonin gene\u2010related peptide staining was quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Perception of warm, cold and heat pain and nerve fibre density were reduced in the painful areas compared with the control sites and with healthy controls. Warm and cold detection thresholds correlated best with epidermal innervation density, whereas heat and cold pain thresholds and axon reflex flare correlated best with dermal innervation density. Clinical pain ratings correlated only with epidermal nerve fibre density (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">r<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009=\u20090.38,\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009&lt;\u20090.05) and better preserved cold detection thresholds (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">r<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009=\u20090.39,\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009&lt;\u20090.05), but not with other assessed functional and structural parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thermal thresholds, axon reflex measurements and assessment of skin innervation density are valuable tools to characterize and quantify peripheral neuropathy and link neuronal function to different layers of the skin. The severity of small fibre neuropathy, however, did not correspond to clinical pain intensity and a specific parameter or pattern that would predict pain intensity in peripheral neuropathy could not be identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/j.1532-2149.2012.00157.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T09:27:30Z","timestamp":1336037250000},"page":"1414-1425","source":"Crossref","is-referenced-by-count":46,"title":["Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients"],"prefix":"10.1002","volume":"16","author":[{"given":"M.","family":"Schley","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rukwied","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dusch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Kantonsspital Luzern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Benrath","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Geber","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center of the Johannes Gutenberg\u2010University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Birklein","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center of the Johannes Gutenberg\u2010University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"H\u00e4ggl\u00f6f","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D  Soedertaelje Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sj\u00f6gren","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D  Soedertaelje Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gee","sequence":"additional","affiliation":[{"name":"Center for Neuropharmacology &amp; Neuroscience Albany Medical College  NY USA"},{"name":"Integrated Tissue Dynamics LLC  Rensselaer NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Center for Neuropharmacology &amp; Neuroscience Albany Medical College  NY USA"},{"name":"Integrated Tissue Dynamics LLC  Rensselaer NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.L.","family":"Rice","sequence":"additional","affiliation":[{"name":"Center for Neuropharmacology &amp; Neuroscience Albany Medical College  NY USA"},{"name":"Integrated Tissue Dynamics LLC  Rensselaer NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schmelz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Medical Faculty Mannheim Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.09.026"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.10.035"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2011.03.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.06.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2009.00241.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6.917"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21527"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.09.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.02.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02969.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2006.06.002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90143-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn093"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.4.510"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.05.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00291-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.013"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.06.028"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.05.019"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20355"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.09.019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.01.265"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.10.2386"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.3.769"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.01.006"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901510"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03023.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.05.002"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1513"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503264102"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.861"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00481-4"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.10.003"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07236.2001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.002"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.115"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.027"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.11.022"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000047"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.06.034"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh180"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.04.06.dc05-2180"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02446.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer325"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1532-2149.2012.00157.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1532-2149.2012.00157.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:46:34Z","timestamp":1695487594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/j.1532-2149.2012.00157.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,3]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/j.1532-2149.2012.00157.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1532-2149.2012.00157.x","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,3]]}}}