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In this study, we aimed to determine whether radon inhalation actually induced a remission of neuropathic pain and improved the quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, we investigated the antinociceptive effects of radon inhalation in the chronic constriction injury (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>) model of neuropathic pain. We evaluated pain behaviour in mice before and after <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> surgery, using von <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rey test. Pretreated mice received <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> surgery immediately after 24\u2010h inhalation of radon at background (<jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content>) concentration (c. 19\u2009Bq\/m<jats:sup>3<\/jats:sup>), or at a concentration of 1000 or 2000\u2009Bq\/m<jats:sup>3<\/jats:sup>, and post\u2010treated mice inhaled similar levels of radon 2 days after <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> surgery induced mechanical allodynia and hyperalgesia on a plantar surface of mice, as assessed using von <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rey test, and 2000\u2009Bq\/m<jats:sup>3<\/jats:sup> radon inhalation alleviated hyperalgesic conditions 22\u201337% compared to <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content> level concentration. Concurrently, <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> surgery increased norepinephrine (<jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>), tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) concentrations in plasma, and leukocyte migration in paws. Furthermore, <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010induced neuropathy reduced superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) activity. Treatment with radon inhalation, specifically at a concentration of 2000\u2009Bq\/m<jats:sup>3<\/jats:sup>, produced antinociceptive effects, i.e., lowered plasma <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> levels and restored <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> activity, as well as pain\u2010related behaviour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that inhalation of 2000\u2009Bq\/m<jats:sup>3<\/jats:sup> radon prevented and alleviated <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010induced neuropathic pain in 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