{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:25Z","timestamp":1787162845366,"version":"build-2736575974"},"reference-count":78,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Neuropathic pain is severely debilitating and resistant to pharmacological approaches; therefore, the study of therapies to complement its treatment is especially relevant. In a case report study, light\u2010emitting diode therapy (\n LEDT<\/jats:styled-content>\n ) has shown analgesic activity as well as reduced the expression of pro\u2010inflammatory cytokines in a rabbit osteoarthritis model and in calcaneal tendinitis in rats. Although\n LEDT<\/jats:styled-content>\n stimulated morphofunctional recovery after nerve injury in rats, its effect against neuropathic pain has not been tested.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n To that purpose, mice under anaesthesia were subjected to the sciatic nerve crush (\n SNC<\/jats:styled-content>\n ) model. On the seventh post\u2010operative day, after determining analgesic dose (energy density in joules),\n LEDT<\/jats:styled-content>\n (950\u2009nm, 80\u2009m\n W<\/jats:styled-content>\n \/cm\n 2<\/jats:sup>\n , 2.5\u2009\n J<\/jats:styled-content>\n \/cm\n 2<\/jats:sup>\n ) was irradiated, daily for a period of 15 days, on the skin over the crush site.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with the\n SNC<\/jats:styled-content>\n group,\n LEDT<\/jats:styled-content>\n reduced mechanical hypersensitivity but not cold hypersensitivity which is induced by\n SNC<\/jats:styled-content>\n , decreased spinal cord and sciatic nerve levels of tumour necrosis factor alpha (\n TNF<\/jats:styled-content>\n \u2010\u03b1) but did not alter interleukin (\n IL<\/jats:styled-content>\n )\u20101\u03b2 and\n IL<\/jats:styled-content>\n \u201010 levels, and finally, failed to accelerate motor functional recovery and morphological nerve regeneration.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Taken together, these data provide first\u2010hand evidence of\n LEDT<\/jats:styled-content>\n effectiveness against neuropathic pain induced by\n SNC<\/jats:styled-content>\n , with corresponding decrease of pro\u2010inflammatory cytokine levels, both in the sciatic nerve and in the spinal cord, although at a small analgesic dose,\n LEDT<\/jats:styled-content>\n failed to accelerate nerve regeneration.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/j.1532-2149.2012.00280.x","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T08:38:08Z","timestamp":1358757488000},"page":"1193-1204","source":"Crossref","is-referenced-by-count":32,"title":["Light\u2010emitting diode therapy induces analgesia and decreases spinal cord and sciatic nerve tumour necrosis factor\u2010\u03b1 levels after sciatic nerve crush in mice"],"prefix":"10.1002","volume":"17","author":[{"given":"F.J.","family":"Cidral\u2010Filho","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neurobiologia da Dor e Inflama\u00e7\u00e3o Centro de Ci\u00eancias Biol\u00f3gicas Departamento de Ci\u00eancias Fisiol\u00f3gicas Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Neuroci\u00eancias Centro de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"Martins","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurobiologia da Dor e Inflama\u00e7\u00e3o Centro de Ci\u00eancias Biol\u00f3gicas Departamento de Ci\u00eancias Fisiol\u00f3gicas Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Neuroci\u00eancias Centro de Ci\u00eancias 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