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Central alterations have been described in FMS<\/jats:styled-content>, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS<\/jats:styled-content>. 31<\/jats:sup>P M<\/jats:styled-content>agnetic R<\/jats:styled-content>esonance S<\/jats:styled-content>pectroscopy (31<\/jats:sup>P<\/jats:styled-content>\u2010MRS<\/jats:styled-content>) has been used to investigate the metabolism of phosphagens in muscles of FMS<\/jats:styled-content> patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH<\/jats:styled-content> in resting quadriceps muscle of patients with FMS<\/jats:styled-content> (n<\/jats:italic>\u2009=\u200919) and in healthy controls (Controls; n<\/jats:italic>\u2009=\u200914) using 31<\/jats:sup>P<\/jats:styled-content>\u2010MRS<\/jats:styled-content>. It was also investigated whether the concentrations of these substances correlated with measures of pain and\/or physical capacity.<\/jats:p><\/jats:sec>Results<\/jats:title>Significantly lower concentrations of adenosine triphosphate (ATP<\/jats:styled-content>) and phosphocreatinine (PCr<\/jats:styled-content>; 28\u201329% lower) were found in FMS<\/jats:styled-content>. No significant group differences existed with respect to inorganic phosphate (Pi<\/jats:styled-content>), Pi<\/jats:styled-content>\/PCr<\/jats:styled-content> and pH<\/jats:styled-content>. The quadriceps muscle fat content was significantly higher in FMS<\/jats:styled-content> than in Controls [FMS<\/jats:styled-content>: 9.0\u2009\u00b1\u20090.5% vs. Controls: 6.6\u2009\u00b1\u20090.6%; (mean\u2009\u00b1\u2009standard error); P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.005]. FMS<\/jats:styled-content> had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness. In FMS<\/jats:styled-content>, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP<\/jats:styled-content> and PCr<\/jats:styled-content>; no significant correlations were found with pain intensities.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Alterations in intramuscular ATP<\/jats:styled-content>, PCr<\/jats:styled-content> and fat content in FMS<\/jats:styled-content> probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2013.00284.x","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T10:57:35Z","timestamp":1359543455000},"page":"1205-1215","source":"Crossref","is-referenced-by-count":43,"title":["Decreased muscle concentrations of ATP<\/scp> and PCR<\/scp> in the quadriceps muscle of fibromyalgia patients \u2013 A 31<\/sup>P<\/scp>\u2010MRS<\/scp> study"],"prefix":"10.1002","volume":"17","author":[{"given":"B.","family":"Gerdle","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department of Medicine and Health Sciences (IMH) Faculty of Health Sciences Link\u00f6ping University Sweden"},{"name":"Pain and Rehabilitation Centre UHL Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Forsgren","sequence":"additional","affiliation":[{"name":"Center for Medical Image Science and Visualization CMIV Link\u00f6ping University Sweden"},{"name":"Radiation Physics Department of Medicine and Health Sciences Link\u00f6ping University Sweden"},{"name":"Department of Radiation Physics UHL Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Rheumatology Department of clinical and Experimental Medicine Faculty of Health Sciences Link\u00f6ping University Sweden"},{"name":"Clinical Department of Rheumatology UHL Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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