{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:13:40Z","timestamp":1791195220765,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Our previous data have indicated that nerve injury\u2010induced up\u2010regulation of thrombospondin\u20104 (\n TSP4<\/jats:styled-content>\n ) proteins in dorsal spinal cord plays a causal role in neuropathic pain state development in a spinal nerve ligation model. To investigate whether\n TSP4<\/jats:styled-content>\n proteins also contribute to the development of centrally mediated changes in nociception after spinal cord injury (\n SCI<\/jats:styled-content>\n ), we investigated whether\n SCI<\/jats:styled-content>\n induced\n TSP4<\/jats:styled-content>\n dysregulation, and if so, whether this change correlated with changes in nociception in a\n \n T\n 9<\/jats:sub>\n <\/jats:styled-content>\n spinal cord contusion injury model.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Behavioural sensitivity to mechanical, thermal stimuli and locomotor function recovery were tested blindly in\n SCI<\/jats:styled-content>\n or sham rats post\u2010injury. Intrathecal antisense or mismatch control oligodeoxynucleotides were used to treat\n SCI<\/jats:styled-content>\n rats with nociceptive hyperreflexia, and\n W<\/jats:styled-content>\n estern blots were used to measure\n TSP4<\/jats:styled-content>\n protein levels in dorsal spinal cord samples.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n SCI<\/jats:styled-content>\n induced below\u2010level hindpaw hypersensitivity to stimuli.\n TSP4<\/jats:styled-content>\n protein levels are up\u2010regulated in dorsal spinal cord of\n SCI<\/jats:styled-content>\n rats with nociceptive hyperreflexia, but not in\n SCI<\/jats:styled-content>\n rats without nociceptive hyperreflexia. There was no significant difference in motor function recovery post\u2010injury between\n SCI<\/jats:styled-content>\n rats with or without nociceptive hyperreflexia. Intrathecal treatment with\n TSP4<\/jats:styled-content>\n antisense, but not mismatch control, oligodeoxynucleotides led to reversal of injury\u2010induced\n TSP4<\/jats:styled-content>\n up\u2010regulation and nociceptive hyperreflexia in\n SCI<\/jats:styled-content>\n rats.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n SCI<\/jats:styled-content>\n leads to\n TSP4<\/jats:styled-content>\n up\u2010regulation in lumbar spinal cord that may play a critical role in mediating centrally mediated behavioural hypersensitivity. Blocking this pathway may be helpful in management of\n SCI<\/jats:styled-content>\n \u2010induced changes in nociception.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/j.1532-2149.2013.00326.x","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T07:24:46Z","timestamp":1367911486000},"page":"1458-1464","source":"Crossref","is-referenced-by-count":15,"title":["Thrombospondin\u20104 contributes to spinal cord injury\u2010induced changes in nociception"],"prefix":"10.1002","volume":"17","author":[{"given":"J.","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Perioperative Care University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Care University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Care University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Reeve\u2010Irvine Research Center University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Steward","sequence":"additional","affiliation":[{"name":"Reeve\u2010Irvine Research Center University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zaucke","sequence":"additional","affiliation":[{"name":"Medical Faculty Center for Biochemistry and Center for Molecular Medicine University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.D.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Care University of California Irvine USA"},{"name":"Department of Pharmacology University of California Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.51"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.05.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.12.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.26"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101161"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.10.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0003-06.2006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_2_8_17_1","first-page":"91","article-title":"A rat pain model of vincristine\u2010induced neuropathy","volume":"99","author":"Higuera E.S.","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2009.112"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6494-11.2012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2982-04.2004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771501316919111"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150360547099"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199701000-00037"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101116"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.21855"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03178-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)29033-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0899022042000201272"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.04.013"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1532-2149.2013.00326.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1532-2149.2013.00326.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:00:51Z","timestamp":1696611651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/j.1532-2149.2013.00326.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/j.1532-2149.2013.00326.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1532-2149.2013.00326.x","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}