{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:23:25Z","timestamp":1791919405099,"version":"4.3.4"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The function of brain networks can be changed in a maladaptive manner in response to chronic neuropathic pain. Analgesics can reduce pain by acting on such networks via direct or indirect (peripheral or spinal) mechanisms. This investigation aimed to map gabapentin's pharmacodynamics (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) in the rodent brain following induction of neuropathic pain in order to further understand its <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pharmacological magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">phMRI<\/jats:styled-content>) and a novel functional connectivity analysis procedure were performed following vehicle or gabapentin treatment in the rat spinal nerve ligation (<jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>) model of neuropathic pain as well as sham animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">phMRI<\/jats:styled-content> performed in <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content> animals revealed robust gabapentin\u2010induced responses throughout the hippocampal formation, yet significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, corrected for multiple comparisons) responses were also measured in other limbic structures and the sensorimotor system. In comparison, sham animals displayed weaker and less widespread <jats:styled-content style=\"fixed-case\">phMRI<\/jats:styled-content> signal changes subsequent to gabapentin treatment. Next, communities of networks possessing strong functional connectivity were elucidated in vehicle\u2010treated <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content> and sham animals. We observed that <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content> and sham animals possessed distinct functional connectivity signatures. When measuring how gabapentin altered the behaviour of the discovered networks, a decrease in functional connectivity driven by gabapentin was not only observed, but the magnitude of this <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> effect was greater in <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content> animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">phMRI<\/jats:styled-content> and functional connectivity analysis approaches, the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> effects of gabapentin in a preclinical neuropathic pain state were characterized. Furthermore, the current results offer insights on which brain systems gabapentin directly or indirectly acts upon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2013.00364.x","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T10:46:56Z","timestamp":1373971616000},"page":"223-237","source":"Crossref","is-referenced-by-count":17,"title":["Gabapentin\u2010induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain"],"prefix":"10.1002","volume":"18","author":[{"given":"B.A.","family":"Hooker","sequence":"first","affiliation":[{"name":"Integrated Science and Technology Abbvie Inc.  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