{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:13:41Z","timestamp":1791195221997,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Injury to the trigeminal nerve often results in the development of chronic pain states including tactile allodynia, or hypersensitivity to light touch, in orofacial area, but its underlying mechanisms are poorly understood. Peripheral nerve injury has been shown to cause up\u2010regulation of thrombospondin\u20104 (<jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content>) in dorsal spinal cord that correlates with neuropathic pain development. In this study, we examined whether injury\u2010induced <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> is critical in mediating orofacial pain development in a rat model of chronic constriction injury to the infraorbital nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Orofacial sensitivity to mechanical stimulation was examined in a unilateral infraorbital nerve ligation rat model. The levels of <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> in trigeminal ganglia and associated spinal subnucleus caudalis and <jats:styled-content style=\"fixed-case\">C1\/C2<\/jats:styled-content> spinal cord (<jats:styled-content style=\"fixed-case\">Vc\/C2<\/jats:styled-content>) from injured rats were examined at time points correlating with the initiation and peak orofacial hypersensitivity. <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> antisense and mismatch oligodeoxynucleotides were intrathecally injected into injured rats to see if antisense oligodeoxynucleotide treatment could reverse injury\u2010induced <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> up\u2010regulation and orofacial behavioural hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data indicated that trigeminal nerve injury induced <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> up\u2010regulation in <jats:styled-content style=\"fixed-case\">Vc\/C2<\/jats:styled-content> at a time point correlated with orofacial tactile allodynia. In addition, intrathecal treatment with <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> antisense, but not mismatch, oligodeoxynucleotides blocked both injury\u2010induced <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> up\u2010regulation in <jats:styled-content style=\"fixed-case\">Vc\/C2<\/jats:styled-content> and behavioural hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support that infraorbital nerve injury leads to <jats:styled-content style=\"fixed-case\">TSP4<\/jats:styled-content> up\u2010regulation in trigeminal spinal complex that contributes to orofacial neuropathic pain states. Blocking this pathway may provide an alternative approach in management of orofacial neuropathic pain states.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2013.00396.x","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T02:36:47Z","timestamp":1378780607000},"page":"489-495","source":"Crossref","is-referenced-by-count":23,"title":["Trigeminal nerve injury\u2010induced thrombospondin\u20104 up\u2010regulation contributes to orofacial neuropathic pain states in a rat model"],"prefix":"10.1002","volume":"18","author":[{"given":"K.\u2010W.","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology and Perioperative Care University of California, Irvine  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u2010S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Perioperative Care University of California, Irvine  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zaucke","sequence":"additional","affiliation":[{"name":"Center for Biochemistry and Center for Molecular Medicine Medical Faculty University of Cologne  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.D.","family":"Luo","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Perioperative Care University of California, Irvine  USA"},{"name":"Department of Pharmacology University of California, Irvine  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00024-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6769"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X97221485"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.11.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-78"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283086781"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2260-07.2007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/19424396.2006.12222229","article-title":"Persistent orodental pain, atypical odontalgia, and phantom tooth pain: When are they neuropathic disorders","volume":"34","author":"Clark G.T.","year":"2006","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-000-0006-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.12.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00017-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277274.83301.c0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01524.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.06.083"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385198-7.00009-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259085.61898.9e"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6494-11.2012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030401"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.12.060"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.04.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3365-09.2009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1988.tb01047.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385198-7.00008-4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1876386300902010076"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07747.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00214-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.05.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.07.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532\u20102149.2013.00326.x"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1532-2149.2013.00396.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1532-2149.2013.00396.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T21:35:27Z","timestamp":1696628127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/j.1532-2149.2013.00396.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,9]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/j.1532-2149.2013.00396.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1532-2149.2013.00396.x","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,9]]}}}