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Although the pathogenesis of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> is not yet completely understood, predicting the future development of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> and chronic pain is a major challenge with great potential advantages, both from an individual as well as an epidemiological standpoint. Current knowledge indicates a genetic underpinning for <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>, and as increasing data are accumulated regarding the genetics involved, the prospect of utilizing these data for prediction becomes ever more attractive. The co\u2010existence of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> with multiple other functional disorders indicates that the clinical identification of such symptom constellations in a patient can alert the physician to the future development of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>. Hypermobility syndrome is another clinical (as well as genetic) phenotype that has emerged as a risk factor for the development of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>. Stressful events, including early life trauma, are also harbingers of the future development of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>. Functional neuroimaging may help to elucidate the neural processes involved in central sensitization, and may ultimately also evolve into markers of predictive value. Last but not least, obesity and disturbed sleep are clinical (inter\u2010related) features relevant for this spectrum. Future efforts will aim at integrating genetic, clinical and physiological data in the prediction of <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> and chronic pain.<\/jats:p>","DOI":"10.1002\/j.1532-2149.2014.00481.x","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T03:17:57Z","timestamp":1394594277000},"page":"1060-1066","source":"Crossref","is-referenced-by-count":8,"title":["Predicting fibromyalgia, a narrative review: Are we better than fools and children?"],"prefix":"10.1002","volume":"18","author":[{"given":"J.N.","family":"Ablin","sequence":"first","affiliation":[{"name":"Institute of Rheumatology Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University  Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Buskila","sequence":"additional","affiliation":[{"name":"Department of Medicine H. 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