{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:48:11Z","timestamp":1761238091626},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human experimental pain models play an important role in studying neuropathic pain mechanisms. The objective of the present study was to test the reproducibility of the topical menthol model over a 1\u2010week period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed an open, two\u2010period study in 10 healthy volunteers with 40 menthol applications. The side of menthol application was randomly assigned. Two trial periods were separated by 1 week. Before and after applying menthol, selected quantitative sensory testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) was performed. The area of mechanical pin\u2010prick hyperalgesia was quantified. Spontaneous pain was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Application of menthol induced a statistically significant decrease in the cold pain threshold (<jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and mechanical pain threshold and an increase in the mechanical pain sensitivity (<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), indicating cold and mechanical (pin\u2010prick) hyperalgesia. Test\u2013retest reliability was best for <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u2009=\u20090.959) and <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u2009=\u20090.930). Intraclass correlation values showed excellent reliability for cold pain and <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u2009=\u20090.96, 0.89). The <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> values post\u2010menthol showed high inter\u2010period correlation factors and no significant inter\u2010period differences (paired <jats:italic>t<\/jats:italic>\u2010test, <jats:italic>t<\/jats:italic>\u2009=\u20091.767\u22121.361; <jats:italic>p<\/jats:italic>\u2009=\u20090.111\u22120.988). The area size of mechanical hyperalgesia was not reliably reproducible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For an observation period of 1 week, the signs of cold and mechanical hyperalgesia were reproducible with a highly significant correlation of about <jats:italic>r<\/jats:italic>\u2009=\u20090.8 and good agreement except for the area size of mechanical pin\u2010prick hyperalgesia. These results demonstrate that the topical menthol pain model is suitable for pharmacological interventions repeated within an observation period of 1 week.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1532-2149.2014.484.x","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T09:50:20Z","timestamp":1398765020000},"page":"1248-1258","source":"Crossref","is-referenced-by-count":16,"title":["Topical high\u2010concentration menthol: Reproducibility of a human surrogate pain model"],"prefix":"10.1002","volume":"18","author":[{"given":"F.","family":"Mahn","sequence":"first","affiliation":[{"name":"Division of Neurological Pain Research and Therapy Department of Neurology Christian\u2010Albrechts\u2010Universit\u00e4t Kiel  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"H\u00fcllemann","sequence":"additional","affiliation":[{"name":"Division of Neurological Pain Research and Therapy Department of Neurology 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