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A systematic review following\n                    <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                    guidelines was performed to evaluate the existing evidence from the literature related to the presence of central sensitization (\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    ) in patients with\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    .Electronic databases PubMed and Web of Science were searched to identify relevant articles using pre\u2010defined keywords regarding\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    . Full\u2010text clinical reports addressing studies of\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    in human adults with chronic complaints due to osteoarthritis were included and screened for methodological quality by two independent reviewers. From the 40 articles that were initially eligible for methodological quality assessment, 36 articles achieved sufficient scores and therefore were discussed. The majority of these studies were case\u2013control studies and addressed\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    of the knee joint. Different subjective and objective parameters considered manifestations of\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    , which have been previously reported in other chronic pain conditions such as whiplash or rheumatoid arthritis, were established in subjects with\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    pain. Overall results suggest that, although peripheral mechanisms are involved in\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    pain, hypersensitivity of the\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    plays a significant role in a subgroup of subjects within this population. Although the majority of the literature provides evidence for the presence of\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    in chronic\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    pain, clinical identification and treatment of\n                    <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    is still in its infancy, and future studies with good methodological quality are necessary.\n                  <\/jats:p>","DOI":"10.1002\/j.1532-2149.2014.499.x","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T08:13:09Z","timestamp":1396512789000},"page":"1367-1375","source":"Crossref","is-referenced-by-count":325,"title":["Evidence for central sensitization in patients with 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