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A dose of 30 mg usually produces peak plasma concentrations within 3 hours after oral ingestion and has a mean half\u2010life of 10 to 15 hours. Thus, temazepam is absorbed more slowly and metabolized more quickly than flurazepam, the only other benzodiazepine marketed in the United States specifically for insomnia. Eight sleep laboratory and 21 clinical studies on temazepam indicate that temazepam reduces awakening during the night and increases sleep duration. However, there was no consistent evidence that temazepam reduces sleep latency \u2014 probably because temazepam, taken at bedtime, does not reach sufficiently high blood levels in time to affect sleep onset. One sleep laboratory study on 8 insomniac patients given 35 consecutive nightly doses of 30 mg found no evidence of tolerance or rebound insomnia. Studies on tolerance, metabolism and carry\u2010over effects have shown that temazepam has no long\u2010acting metabolites and does not affect waking function following use at bedtime. In patients for whom hypnotic medication is appropriate, temazepam should be an effective drug for reducing most symptoms of insomnia.<\/jats:p>","DOI":"10.1002\/j.1875-9114.1981.tb03546.x","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T09:01:16Z","timestamp":1450256476000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of Temazepam as a Hypnotic"],"prefix":"10.1002","volume":"1","author":[{"given":"Merrill M.","family":"Mitler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600530602"},{"key":"e_1_2_1_3_2","first-page":"875","article-title":"Pharmacokinetics of benzodiazepines. 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