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Although benoxaprofen is a relatively weak inhibitor of cyclo\u2010oxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation, it has not been established that it is unique with regard to these actions. Benoxaprofen undergoes hepatic metabolism via glucuronidation as the primary route of elimination and has a half\u2010life of 28\u201335 hr. Clinical trials have demonstrated that its analgesic and anti\u2010inflammatory properties are useful in the management of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Once daily dosing of 300\u2013600 mg is effective for many patients. In addition to gastrointestinal intolerance, photosensitivity and onycholysis are the most frequent adverse effects encountered. Recent reports of fatal cholestatic jaundice often associated with nephrotoxicity led to the withdrawal of benoxaprofen from world markets. It is uncertain whether it will once again be available for clinical use.<\/jats:p>","DOI":"10.1002\/j.1875-9114.1982.tb03212.x","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T20:56:47Z","timestamp":1450299407000},"page":"354-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pharmacology, Clinical Efficacy, and Adverse Effects of the Nonsteroidal Anti\u2010Inflammatory Agent Benoxaprofen"],"prefix":"10.1002","volume":"2","author":[{"given":"Stephen L.","family":"Dahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Investigator's reference manual","author":"Eli Lilly and 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