{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:10:24Z","timestamp":1761066624935,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T00:00:00Z","timestamp":1327363200000},"content-version":"vor","delay-in-days":9569,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[1985,11,12]]},"abstract":"<jats:p>To evaluate the steady\u2010state bioequivalence of the nonsteroidal antiinflammatory analgesic agent, diflunisal, administered once versus twice daily, 13 healthy volunteers received diflunisal as follows: (1) 1000 mg at 8:00 am and (2) 500 mg at 8:00 am and 8:00 pm, each for 14 days in a randomized crossover study. The mean (\u00b1 SD) steady\u2010state peak plasma concentrations were significantly greater after once\u2010daily dosing (186 \u00b1 25 \u03bcg\/ml vs 150 \u00b1 37 \u03bcg\/ml; p &lt; 0.01). The time to peak concentration was also longer after the single\u2010dose regimen (2.5 \u00b1 0.8 vs 1.9 \u00b1 0.9 hr; p &lt; 0.05). The regimens were similar with respect to the mean 24\u2010hour area under the plasma concentration\u2010time curve at steady state (2839 \u00b1 612 vs 2782 \u00b1 778 \u03bcg\u00b7hr\u00b7ml<jats:sup>\u22121<\/jats:sup>), steady\u2010state plasma concentrations (118 \u00b1 25 vs 116 \u00b1 32 \u03bcg\/ml), trough plasma concentration (85 \u00b1 27 vs 92 \u00b1 28 \u03bcg\/ml) as well as 24\u2010hour urinary excretion (776 \u00b1 79 vs 771 \u00b1 89 mg) of diflunisal. Based on urinary recoveries, the bioequivalence ratio (once vs twice daily) was 1.01 \u00b1 0.08. These results indicate that diflunisal administered once daily might offer comparable therapeutic effects but be more convenient than a twice\u2010daily regimen.<\/jats:p>","DOI":"10.1002\/j.1875-9114.1985.tb03440.x","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T07:24:40Z","timestamp":1450250680000},"page":"336-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Steady\u2010state Disposition of Diflunisal: Once\u2010 versus Twice\u2010daily Administration"],"prefix":"10.1002","volume":"5","author":[{"given":"Parviz","family":"Mojaverian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Mario L.","family":"Rocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian N.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Vlasses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanassios N.","family":"Chremos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juang C.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger K.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1977.tb04510.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1977.tb04511.x"},{"volume-title":"Diflunisal in clinical practice","year":"1977","author":"Caruso I","key":"e_1_2_1_4_2"},{"volume-title":"Diflunisal in clinical practice","year":"1977","author":"Tait GBW","key":"e_1_2_1_5_2"},{"key":"e_1_2_1_6_2","first-page":"245","article-title":"Pharmacokinetics of MK\u2010647, a novel salicylate","volume":"17","author":"Steelman SL","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb00932.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0090-9556(25)05767-8","article-title":"Physiological disposition and metabolism of 5\u2010(2\u2032,4\u2032\u2010difluorophenyl) salicylic acid, a new salicylate","volume":"3","author":"Tocco DJ","year":"1975","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1983.3.2p2.9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700110"},{"key":"e_1_2_1_11_2","first-page":"52","article-title":"Nonlinear pharmacokinetics of diflunisal (abstr)","author":"Yeh KE","year":"1982","journal-title":"Proc Acad Pharm Sci"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007997809108993"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.1985.tb03440.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.1985.tb03440.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1875-9114.1985.tb03440.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:33:36Z","timestamp":1761064416000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/j.1875-9114.1985.tb03440.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,11,12]]}},"alternative-id":["10.1002\/j.1875-9114.1985.tb03440.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1875-9114.1985.tb03440.x","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[1985,11,12]]},"assertion":[{"value":"2012-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}