{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:10:01Z","timestamp":1761102601322,"version":"build-2065373602"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T00:00:00Z","timestamp":1327363200000},"content-version":"vor","delay-in-days":9331,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[1986,7,8]]},"abstract":"<jats:p>Methotrexate, a folic acid antagonist, is being employed more frequently in an attempt to control rheumatoid arthritis that has not responded adequately to conventional therapies. Systemic administration of 7.5\u201315 mg weekly in a pulse fashion appears to be effective without precipitating serious adverse effects. Concern over potentially serious adverse effects and lack of well\u2010controlled clinical trials have limited its use to severe, refractory disease. Its use in the future is likely to increase in these patients because of its ease of administration and the high response rate noted in clinical studies.<\/jats:p>","DOI":"10.1002\/j.1875-9114.1986.tb03472.x","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T13:21:25Z","timestamp":1450272085000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methotrexate in Rheumatoid Arthritis: An Update"],"prefix":"10.1002","volume":"6","author":[{"given":"Donald R.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J.","family":"DeJong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus J.","family":"Fiechtner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"312","article-title":"Clinical trial of amethopterin (methotrexate) in psoriatic and rheumatoid arthritis (preliminary report)","volume":"5","author":"O'Brien WM","year":"1962","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_2","first-page":"349","article-title":"The use of methotrexate in rheumatoid arthritis","volume":"9","author":"Letendre PW","year":"1985","journal-title":"Drug Intell Clin Pharm"},{"key":"e_1_2_1_4_2","first-page":"3","volume-title":"Cancer chemotherapy handbook","author":"Dorr RT","year":"1980"},{"key":"e_1_2_1_5_2","first-page":"1","volume-title":"Cancer chemotherapy","author":"Cline MJ","year":"1980"},{"key":"e_1_2_1_6_2","first-page":"1272","volume-title":"The pharmacological basis of therapeutics","author":"Calabresi P","year":"1980"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197312062892307"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(73)90062-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197801)41:1<36::AID-CNCR2820410108>3.0.CO;2-I"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1182\/blood.V27.1.38.38","article-title":"Inhibition of local inflammatory response in man by antimetabolites","volume":"27","author":"Hersh EM","year":"1966","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb47002.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160114"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.47.4.305"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1710970223"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.24.583"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-489"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"key":"e_1_2_1_18_2","first-page":"5","article-title":"Measurement of red blood cell methotrexate concentrations and lymphocyte subsets during therapy of rheumatoid arthritis","volume":"3","author":"Duby S","year":"1985","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197511)36:5<1619::AID-CNCR2820360514>3.0.CO;2-G"},{"key":"e_1_2_1_20_2","first-page":"1","article-title":"Clinical pharmacokinetics of methotrexate","volume":"3","author":"Shen DD","year":"1978","journal-title":"Drugs"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1984.47"},{"key":"e_1_2_1_22_2","first-page":"193","article-title":"Pharmacokinetics of low\u2010dose methotrexate in rheumatoid arthritis (abstr)","volume":"39","author":"Furst DE","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92105-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250312"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.1.64"},{"key":"e_1_2_1_26_2","first-page":"18","article-title":"Treatment of rheumatoid arthritis with methopterin (methotrexate)","author":"Vogler WR.","year":"1970","journal-title":"Clin Res"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000130035004"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92925-6"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91250-2"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709110154"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.351"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230121"},{"key":"e_1_2_1_33_2","first-page":"501","article-title":"Low\u2010dose pulse methotrexate therapy in rheumatoid arthritis","volume":"7","author":"Willkens RF","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_34_2","first-page":"314","article-title":"Methotrexate: a perspective of its use in the treatment of rheumatic diseases","volume":"100","author":"Willkens RF","year":"1982","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_35_2","first-page":"S65","article-title":"Oral methotrexate therapy in rheumatoid arthritis","volume":"25","author":"Zeiders RS.","year":"1982","journal-title":"(abst) Arthritis Rheum"},{"key":"e_1_2_1_36_2","first-page":"S65","article-title":"Pulsed intravenous treatment in rheumatoid arthritis","volume":"25","author":"Bachman DM.","year":"1982","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90477-1"},{"key":"e_1_2_1_38_2","first-page":"860","article-title":"Low\u2010dose methotrexate in rheumatoid arthritis","volume":"9","author":"Steinsson K","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(83)90014-8"},{"key":"e_1_2_1_40_2","first-page":"161","article-title":"Combined cytotoxic therapy in rheumatoid arthritis (RA)","volume":"14","author":"Fosdick WM.","year":"1971","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_41_2","first-page":"S37","article-title":"Pulse methotrexate therapy for intractable rheumatoid cutaneous ulcers (abstr)","volume":"28","author":"Tilinkos N.","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_42_2","first-page":"760","article-title":"A controlled two\u2010centre trial of parenteral methotrexate therapy for refractory rheumatoid arthritis","volume":"11","author":"Thompson RN","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_43_2","first-page":"S57","article-title":"Azathioprine compared with methotrexate in the treatment of rheumatoid arthritis\u2014results of a double\u2010blind 24\u2010week trial","volume":"27","author":"McKendry R","year":"1984","journal-title":"(abst) Arthritis Rheum"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280702"},{"key":"e_1_2_1_45_2","first-page":"S87","article-title":"Effect of increasing dose of methotrexate in patients with rheumatoid arthritis (abst)","volume":"28","author":"Williams HJ.","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270525"},{"key":"e_1_2_1_47_2","first-page":"405","article-title":"Remission\u2010inducing drugs in rheumatoid arthritis","volume":"122","author":"Anastassiades TP.","year":"1980","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_48_2","first-page":"S75","article-title":"Methotrexate is safe and effective in the long\u2010term management of rheumatoid arthritis (abst)","volume":"28","author":"Weinstein A","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290127"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-4-619"},{"key":"e_1_2_1_51_2","first-page":"S56","article-title":"Incidence of untoward reactions in patients with rheumatoid arthritis treated with methotrexate","volume":"26","author":"Wilke WS","year":"1983","journal-title":"(abst) Arthritis Rheum"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260523"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640260091025"},{"key":"e_1_2_1_54_2","first-page":"208","article-title":"Benefits and adverse drug experiences during long\u2010term methotrexate treatment of 248 psoriatics","volume":"25","author":"Nyfors A.","year":"1978","journal-title":"Dan Med Bull"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.3109\/01485017908985067"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-1-84"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290118"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(85)90029-0"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261021"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5750.625"},{"key":"e_1_2_1_61_2","first-page":"S29","article-title":"Methotrexate and the liver","volume":"12","author":"Tolman KG","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5801.654"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620220008002"},{"key":"e_1_2_1_64_2","first-page":"615","article-title":"Long\u2010term therapy of psoriatic and rheumatoid arthritis with oral methotrexate monitored by serial liver biopsies","volume":"22","author":"Gowans JDC","year":"1979","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_65_2","first-page":"S37","article-title":"Hepatic histology following prolonged treatment of rheumatoid arthritis with bolus methotrexate (abstr)","volume":"28","author":"Aponte J","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_66_2","first-page":"S14","article-title":"Liver histology in rheumatoid arthritis before and after prolonged methotrexate therapy (abstr)","volume":"28","author":"Koo AP","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_67_2","first-page":"S77","article-title":"Liver biopsies in patients on low\u2010dose pulse methotrexate for the treatment of rheumatoid arthritis (abstr)","volume":"28","author":"Willkens RF","year":"1985","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308193"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80064-9"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03250040013017"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261015"},{"key":"e_1_2_1_72_2","first-page":"463","article-title":"Problems of methotrexate administration","volume":"15","author":"Young P","year":"1972","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261016"},{"key":"e_1_2_1_74_2","first-page":"923","article-title":"Methotrexate therapy and pulmonary disease","volume":"207","author":"Schwartz KR","year":"1969","journal-title":"JAMA"},{"key":"e_1_2_1_75_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/archderm.1971.04000140080014","article-title":"Severe pneumonitis during methotrexate therapy","volume":"103","author":"Goldman GC","year":"1971","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_76_2","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/archinte.1985.00360110105023","article-title":"Pneumonitis complicating low\u2010dose methotrexate therapy in rheumatoid arthritis","volume":"145","author":"Clair EW","year":"1985","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90786-5"},{"key":"e_1_2_1_78_2","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1002\/art.1780280224","article-title":"Toxicity to methotrexate in rheumatoid arthritis: clinical and HLA studies (abstr)","volume":"28","author":"Alarcon GS","year":"1985","journal-title":"Arthritis Rheum"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.1986.tb03472.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.1986.tb03472.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1875-9114.1986.tb03472.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:47:45Z","timestamp":1761054465000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/j.1875-9114.1986.tb03472.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7,8]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,7,8]]}},"alternative-id":["10.1002\/j.1875-9114.1986.tb03472.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1875-9114.1986.tb03472.x","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[1986,7,8]]},"assertion":[{"value":"2012-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}