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Although intravenous acetaminophen generally improved pain relief and demonstrated opioid\u2010sparing effects compared with placebo, it did not consistently reduce the frequency of opioid\u2010related adverse events (e.g., postoperative nausea and vomiting). The safety and efficacy of intravenous acetaminophen as an antipyretic agent have been documented in adults and children; however, its cost is several\u2010fold higher than that of the oral and rectal formulations. Although use of intravenous acetaminophen has reduced other postoperative resource utilization (e.g., hospital length of stay) in some studies outside the United States in patients undergoing abdominal surgery, a full economic evaluation in the United States has yet to be undertaken. In addition, its administration time (15\u2010min infusion) and packaging (glass, single\u2010use vial) have the potential to adversely affect patient flow in the postanesthesia care unit, create burden on patient care units, and lead to drug waste. Furthermore, 1\u00a0g of intravenous acetaminophen is formulated in 100\u00a0ml of solution, which may be an issue for patients with fluid restrictions. 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