{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:50:19Z","timestamp":1792111819084,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Despite the wide array of antihypertensive agents and the availability of national guidelines regarding treatment for hypertension, the disease remains uncontrolled in nearly 50% of affected patients. Furthermore, the number of patients with resistant hypertension continues to increase. For patients with resistant hypertension, the American Heart Association has advocated for clinical studies to determine appropriate pharmacologic treatment strategies. One proposed strategy involves ambulatory measurement of plasma renin activity (<jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content>) to guide the selection of antihypertensive therapy. Patients with low <jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content> would be prescribed natriuretic volume\u2010mediated therapies (e.g., diuretics and calcium channel blockers), whereas those with high <jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content> would receive antirenin system therapies (e.g., \u03b2\u2010blockers, angiotensin\u2010converting enzyme inhibitors, and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers). This review focuses on the principles of <jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content>\u2010guided therapy, its historical development, alternative approaches to classifying patients into categories of response to antihypertensive agents, and recent data supporting the use of plasma renin activity\u2013guided hypertension management.<\/jats:p>","DOI":"10.1002\/j.1875-9114.2012.01031.x","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T03:57:21Z","timestamp":1346817441000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Plasma Renin Activity\u2013Guided Strategy for the Management of Hypertension"],"prefix":"10.1002","volume":"32","author":[{"given":"Nicole","family":"Olson","sequence":"first","affiliation":[{"name":"Pharmacy Service Veterans Affairs Medical Center Tomah Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"DeJongh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy Concordia University Wisconsin Mequon Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustus","family":"Hough","sequence":"additional","affiliation":[{"name":"Pharmacy Service Veterans Affairs Medical Center West Palm Beach Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Parra","sequence":"additional","affiliation":[{"name":"Pharmacy Service Veterans Affairs Medical Center West Palm Beach Florida"},{"name":"Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"103","article-title":"Vital signs: prevalence, treatment, and control of hypertension \u2014 United States, 1999\u20132002 and 2005\u20132008","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2002.02045.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01317-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90128-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02097-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02195-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.63"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.324"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(03)00867-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000091267.39066.72"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.04.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.148023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.114"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.135"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/clinchem\/37.10.1811","article-title":"Plasma renin activity and plasma prorenin assays","volume":"37","author":"Sealey JE","year":"1991","journal-title":"Clin Chem"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02156-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.98"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)01280-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.139"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90054-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07614-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.5.525"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.13.1168"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.105"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2003.08.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(96)00022-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00080-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.169961"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.123"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.001"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.131235"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.07.021"},{"key":"e_1_2_8_36_1","volume-title":"Clinical trials.gov [Internet]","author":"Alderman MH","year":"2000"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.171"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.2012.01031.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1875-9114.2012.01031.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:29:58Z","timestamp":1761046198000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/j.1875-9114.2012.01031.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/j.1875-9114.2012.01031.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1875-9114.2012.01031.x","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,9]]},"assertion":[{"value":"2012-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}