{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:42:14Z","timestamp":1761093734875,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:00:00Z","timestamp":1333065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Pharmacotherapeutic approaches for the management of pulmonary arterial hypertension (PAH) have expanded greatly in the last 10\u00a0years. Pulmonary arterial hypertension is a relatively rare disease and is associated with myriad disease processes. The older term for PAH, primary PAH, has been changed to represent these differences and to distinguish it from postcapillary PAH associated with left\u2010sided heart failure. Limitations in evaluating treatment approaches for PAH include its rarity, the small number of patients included in clinical trials, and issues regarding the use of placebo\u2010controlled trials in a disease with such a high mortality rate if left untreated. Management options include the use of prostacyclin and prostacyclin analogues, endothelin receptor antagonists, and phosphodiesterase inhibitors, as well as traditional background therapy with diuretics, digoxin, calcium channel blockers, and warfarin. Numerous drugs are under investigation to evaluate their possible roles in management. Combination therapy is increasingly becoming a standard approach to therapy, with mounting literature to document effectiveness. Current or emerging roles for the pharmacist in the management of PAH largely involves ensuring access to drug therapy, facilitating specialty pharmacy dispensing, and providing patient counseling. Newer roles may include future drug development, optimized use of investigational drugs, and specialized disease management programs. This compilation includes a series of articles identifying important literature in cardiovascular pharmacotherapy. This bibliography focuses on pharmacotherapeutic management of pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>). Most of the cited works present the results of significant human clinical studies that have shaped the management of patients with <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>. Limited primary literature is available for some topics, so in addition, consensus documents prepared by expert panels are reviewed. This compilation may serve as a teaching tool, reference resource, or update of the literature for pharmacy clinicians, physicians, and students.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1875-9114.2012.01105.x","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T03:54:48Z","timestamp":1346817288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Key Articles and Guidelines in the Management of Pulmonary Arterial Hypertension: 2011 Update"],"prefix":"10.1002","volume":"32","author":[{"given":"Samuel G.","family":"Johnson","sequence":"first","affiliation":[{"name":"Pharmacy Kaiser Permanente Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Kayser","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Attridge","sequence":"additional","affiliation":[{"name":"Feik School of Pharmacy University of the Incarnate Word San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Regis University Rueckert\u2010Harmon College of Health Professions Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyree H.","family":"Kiser","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Colorado Denver School of Pharmacy Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Moote","sequence":"additional","affiliation":[{"name":"University of North Carolina Health Care Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Ohio State University Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo E.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Division of Pharmacotherapy University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Erstad","sequence":"additional","affiliation":[{"name":"Pharmacy Practice University of Arizona College of Pharmacy\u2010Pulido Center Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,30]]},"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1875-9114.2012.01105.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1875-9114.2012.01105.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:50:41Z","timestamp":1761051041000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/j.1875-9114.2012.01105.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,30]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/j.1875-9114.2012.01105.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1875-9114.2012.01105.x","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2012,3,30]]},"assertion":[{"value":"2012-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}