{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:46:33Z","timestamp":1789631193735,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T00:00:00Z","timestamp":1349136000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>To evaluate the impact of a pharmacist\u2010led warfarin patient self\u2010management program on quality of life and anticoagulation control compared with management in a physician\u2010led specialized anticoagulation clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, randomized, controlled, open\u2010label trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 114 patients aged 18\u201375 years who were followed at a specialized anticoagulation clinic, had received warfarin for at least 6 months, and were expected to continue warfarin for a minimum of 4\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>All patients attended an educational session on anticoagulation provided by a pharmacist. Patients randomized to the self\u2010management group (58 patients) also received practical training to use the CoaguChek <jats:styled-content style=\"fixed-case\">XS <\/jats:styled-content>device and a self\u2010management dosing algorithm. Patients in the control group (56 patients) continued to undergo standard management at the anticoagulation clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Patients completed a validated quality\u2010of\u2010life questionnaire and the validated Oral Anticoagulation Knowledge test at the beginning and end of the study. The quality of anticoagulation control was evaluated by using the time spent in therapeutic range. After 4 months of follow\u2010up, a significant improvement in the self\u2010management group was observed compared with the control group in four of the five quality\u2010of\u2010life topics (p&lt;0.05). Improvements in knowledge were observed in both groups after the training session and persisted after 4 months (p&lt;0.05 for all). The time spent in the therapeutic range (80.0% in the self\u2010management group vs 75% in the control group, p=0.79) and in the extended therapeutic range ([target international normalized ratio\u00a0\u00b1\u00a00.3] 93.2% in the self\u2010management group vs 91.1% in the control group, p=0.30) were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A self\u2010management warfarin program led by pharmacists resulted in significant improvement in the quality of life of patients receiving warfarin therapy as well as a reduction in the time required for anticoagulation monitoring, while maintaining a level of anticoagulation control similar to a high\u2010quality specialized anticoagulation clinic.<\/jats:p><\/jats:sec>","DOI":"10.1002\/j.1875-9114.2012.01116","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T09:50:00Z","timestamp":1349171400000},"page":"871-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Impact of a Pharmacist\u2010Led Warfarin Self\u2010Management Program on Quality of Life and Anticoagulation Control: A Randomized Trial"],"prefix":"10.1002","volume":"32","author":[{"given":"Lucie","family":"Verret","sequence":"first","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Couturier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9anne","family":"Rozon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Saudrais\u2010Janecek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"St\u2010Onge","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ars\u00e8ne","family":"Basmadjian","sequence":"additional","affiliation":[{"name":"Department of Medicine Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Faculties of Medicine Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Brouillette","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"de Denus","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montreal Heart Institute\u2013Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Faculties of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"BartholowM.Top 200 prescription drugs of 2010. 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