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In this study, a model nondenaturing carrier comprised of a nanocrystalline (10<jats:sup>\u22127<\/jats:sup> m) tin oxide core and a surface\u2010charge\u2010reducing organic bonding layer (GF292) was synthesized. A subsequently bound protein (human transferrin) showed significant retained conformation by immunoelectron microscopy. In the synthesis of targeted drug systems and vaccines, nanocrystalline cores treated with appropriate surface\u2010modifying agents may be suitable carriers.<\/jats:p>","DOI":"10.1002\/jab.770010404","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T07:01:24Z","timestamp":1104303684000},"page":"289-294","source":"Crossref","is-referenced-by-count":13,"title":["A nondenaturing solid phase pharmaceutical carrier comprised of surface\u2010modified nanocrystalline materials"],"prefix":"10.1002","volume":"1","author":[{"given":"Nir","family":"Kossovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rointan F.","family":"Bunshah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Gelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Sponsler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheerendra M.","family":"Umarjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Gyo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Doerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra V.","family":"Deshpandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"73","volume-title":"Polymers in Biology and Medicine","author":"Varga J. 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