{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:23:46Z","timestamp":1773411826451,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T00:00:00Z","timestamp":1093824000000},"content-version":"vor","delay-in-days":4473,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Biomaterials"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The management of severe burns requires the suppression of bacterial growth, particularly when eschar and damaged tissue are present. For such cases, silver sulfadiazine (AgSD) cream has been traditionally applied. This antibacterial cream, however, cannot be used in conjunction with a temporary wound dressing that is needed to promote healing. The authors developed a synthetic wound dressing with drug deliver capability for clinical use by impregnating a poly\u2010\u2010 spongy matrix with AgSD, which is released in a controlled, sustained fashion. In general, the dressing adhered firmly to the wound in the case of superficial second\u2010degree burns, and during the healing process it separated spontaneously from the re\u2010epithelialized surface. In the management of deep second\u2010degree burns where eschar and damaged tissue were present, the dressing had to be changed at intervals of 3 to 5 days until it adhered firmly to the wound. Once the dressing had firmly attached to the wound, it was left in place until it separated spontaneously from the re\u2010epithelialized surface. Dressing changes were fewer than with other treatments and the pain was effectively reduced. Cleansed wounds were effectively protected from bacterial contamination. Of 52 cases treated with this wound dressing, 93% (14\/15) of superficial second\u2010degree burns, 75% (3\/4) of deep second\u2010degree burns, 85% (6\/7) of superficial and deep second\u2010degree burns, and 75% (12\/16) of split\u2010thickness skin donor sites were evaluated as achieving good or excellent results.<\/jats:p>","DOI":"10.1002\/jab.770030211","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T01:46:44Z","timestamp":1117244804000},"page":"153-161","source":"Crossref","is-referenced-by-count":28,"title":["A silver\u2010sulfadiazine\u2010impregnated synthetic wound dressing composed of poly\u2010l\u2010leucine spongy matrix: An evaluation of clinical cases"],"prefix":"10.1002","volume":"3","author":[{"given":"Yoshimitsu","family":"Kuroyanagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eikichi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kenmochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Shioya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/10731197809118690"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(80)90038-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820160306"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(83)90005-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(83)90006-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(87)90170-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198110000-00005"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7031899"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198809000-00008"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(77)90004-3"},{"key":"e_1_2_1_12_2","first-page":"83","article-title":"Silver\u2010impregnated porcine xenograft for damaged or missing skin","volume":"23","author":"Ersek R. A.","year":"1984","journal-title":"Contemp. Surg."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198408000-00017"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198412000-00004"},{"key":"e_1_2_1_15_2","first-page":"89","article-title":"Efficacy and safety of DIMAC with silver sulfadiazine as compared to silvadene cream in the treatment of full thickness thermal injury","volume":"1988","author":"Miller L.","journal-title":"Abstract of 20th Annual Meeting of American Burn Association, Seattle."},{"key":"e_1_2_1_16_2","first-page":"526","article-title":"Development of wound dressing II. Evaluation of poly\u2010L\u2010leucine wound dressing containing antibacterial drug","volume":"7","author":"Kuroyanagi Y.","year":"1987","journal-title":"J. Jpn. 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