{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:51:05Z","timestamp":1758905465540},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T00:00:00Z","timestamp":1093824000000},"content-version":"vor","delay-in-days":3286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Biomaterials"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a histomorphological and morphometric analysis of the effects of short daily periods of micromotion and phagocytosable particles of high density polyethylene (PE) on bone ingrowth into a 1 \u00d7 1 \u00d7 5 mm canal within a titanium chamber in rabbits. The micromotion chamber (MC) was implanted in the tibia of nine mature New Zealand white rabbits. After osseointegration and first harvest of tissue, 40 micromotions (amplitude = 0.5 mm) were applied daily at a rate of 1 Hz for a 3\u2010week period. The tissue within the chamber was then harvested. For the second treatment, PE particles (10<jats:sup>8<\/jats:sup>\/mL) were placed within the canal. The tissue in the chamber was harvested 3 weeks later. The next treatment was a 3\u2010week rest period, in which neither micromotion nor particles were utilized; a harvest followed. The final treatment combined PE particles and micromotion, followed by a harvest 3 weeks later. Sections from control harvests contained extensive trabecular bone arranged longitudinally throughout the canal in a fibrovascular stroma. Micromotion produced longitudinally oriented fibrous tissue within the chamber. PE particles were associated with macrophages, surrounding and engulfing the birefringent particles. The combination of particles and micromotion produced a fibrous stroma laden with macrophages. PE particles and micromotion, alone or together, produced a similar effect in inhibiting bone ingrowth, compared to nonmoved chambers without particles. In this short\u2010term experiment, no additive or potentiating effect of these two stimuli could be demonstrated. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jab.770060303","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T01:47:19Z","timestamp":1117244839000},"page":"161-165","source":"Crossref","is-referenced-by-count":14,"title":["Intermittent micromotion and polyethylene particles inhibit bone ingrowth into titanium chambers in rabbits"],"prefix":"10.1002","volume":"6","author":[{"given":"Stuart B.","family":"Goodman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Aspenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Regula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lidgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,30]]},"reference":[{"issue":"1","key":"e_1_2_1_2_2","first-page":"11","article-title":"Clinical, radiographic and histologic evaluation of retrieved human noncemented porous coated implants","volume":"1","author":"Cook S. 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