{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:57:42Z","timestamp":1789693062820,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK128562"],"award-info":[{"award-number":["K23DK128562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Am Coll Clin Pharm"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sepsis is a life\u2010threatening medical emergency and a leading cause of morbidity and mortality worldwide. Reductions in time to antibiotics in patients presenting with sepsis or septic shock are associated with reduced mortality, and Surviving Sepsis Campaign guidelines recommend antibiotics within 1\u00a0h of recognition. Pharmacists are well\u2010equipped to help navigate the therapeutic and operational challenges associated with achieving this goal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the association of pharmacist involvement in sepsis response with time to antibiotics in hospitalized patients with sepsis and septic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of the following databases was conducted: PubMed\/MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. Studies must have included a designated role of an individual pharmacist in the management of sepsis or septic shock and not be considered an operational change. The primary outcome of interest was time to antibiotic administration, with secondary outcomes including intensive care unit (ICU) and hospital length of stay as well as in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 10 studies including 1772 patients with sepsis or septic shock that evaluated a sepsis response in which a pharmacist was included. Studies included patients in the ICU, emergency department, and hospital ward setting. Seven studies demonstrated a significant reduction in time to antibiotics, with two other studies supporting this conclusion in extrapolation or sensitivity analysis. There was not a consistent reduction in ICU or hospital length of stay nor in\u2010hospital mortality between those interventions involving a pharmacist compared with their defined control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pharmacist involvement in sepsis response, often as part of a multiprofessional team\u2010based approach to sepsis care, is associated with a reduced time to antibiotic administration for hospitalized patients with sepsis or septic shock.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jac5.1723","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T04:14:53Z","timestamp":1666671293000},"page":"942-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacist involvement in sepsis response and time to antibiotics: A systematic review"],"prefix":"10.1002","volume":"6","author":[{"given":"Payton E.","family":"Atkins","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Thompson Bastin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy  Lexington Kentucky USA"},{"name":"Department of Pharmacy Services University of Kentucky HealthCare  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Medical Center Library University of Kentucky Libraries  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie E.","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy  Lexington Kentucky USA"},{"name":"Department of Pharmacy Services University of Kentucky HealthCare  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-1594","authenticated-orcid":false,"given":"Alexander H.","family":"Flannery","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy  Lexington Kentucky USA"},{"name":"Department of Pharmacy Services University of Kentucky HealthCare  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06151-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1848OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000217961.75225.E9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003921"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003940"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"AtkinsPE Thompson BastinML LaineME FlanneryAH.Pharmacist involvement in sepsis response and time to antibiotics: a systematic review. 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