{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:50:05Z","timestamp":1792194605091,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Am Coll Clin Pharm"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited literature has evaluated strategies to maximize time in therapeutic range (TTR) in patients with left ventricular assist devices (LVADs) maintained on warfarin therapy. In non\u2010LVAD populations, pharmacist\u2010managed warfarin results in higher TTR and improved clinical outcomes. No study has evaluated the impact of pharmacist\u2010managed outpatient warfarin exclusively in HeartMate 3 (HM3, Abbott Medical, Pleasanton, CA) LVAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective cohort study included patients implanted with HM3 LVADs across six medical centers in the United States from January 2019 to May 2023. The study compared pharmacist\u2010managed (RPH) warfarin therapy with usual warfarin care (UC), which was managed by any nonpharmacist clinician. The primary end point was TTR over 1\u2009year using Rosendaal's method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 277 patients were included, 191 in the RPH group and 86 in the UC group. The TTR was 65.6% in the RPH group and 45.8% in the UC group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). This significant difference persisted after adjusting for confounding variables. There was no significant difference in thromboembolic events between groups. There was no difference in bleeding outcomes between groups when Mechanical Circulatory Support\u2014Academic Research Consortium Type 1 bleeding was excluded (RPH 19.3% vs. UC 12.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with HM3 LVADs receiving warfarin, pharmacist\u2010managed warfarin led to a higher TTR compared with UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jac5.70220","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:30:51Z","timestamp":1778729451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing Pharmacist\u2010Managed Warfarin Versus Usual Care in\n                    <scp>HeartMate<\/scp>\n                    3 Patients: A Multicenter Retrospective Observational Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-2940","authenticated-orcid":false,"given":"Bailey M.","family":"Colvin","sequence":"first","affiliation":[{"name":"Department of Pharmacy West Virginia University Medicine  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy West Virginia University Medicine  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Allegheny General Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April S.","family":"Britt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Wellstar Health System  Marietta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cadiz","sequence":"additional","affiliation":[{"name":"University of California Irvine School of Pharmacy &amp; Pharmaceutical Sciences  Irvine California USA"},{"name":"University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9642-3277","authenticated-orcid":false,"given":"Paige","family":"Carrigan","sequence":"additional","affiliation":[{"name":"University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Chu","sequence":"additional","affiliation":[{"name":"University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Faulkenberg","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Kentucky HealthCare  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinn","family":"Floyd","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Allegheny General Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-3706","authenticated-orcid":false,"given":"Ian","family":"Hollis","sequence":"additional","affiliation":[{"name":"University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"},{"name":"Department of Pharmacy University of North Carolina Medical Center  Chapel Hill North Carolina 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