{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:13:52Z","timestamp":1783505632484,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Am Coll Clin Pharm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to describe the development of pharmacist\u2010led clinical services in primary health care (PHC) in a region of S\u00e3o Paulo, Brazil, comparing the profile of patients served, the types of care provided, and the clinical outcomes achieved in the provision of these services in two distinct periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This quantitative, descriptive, retrospective, observational study analyzed data from pharmaceutical consultations conducted in 12 PHC units in S\u00e3o Paulo, Brazil. Data were extracted from the service database and included patient characteristics and lifestyle habits, control of prevalent chronic conditions based on clinical and laboratory parameters, medication use history, identified drug\u2010related problems, and pharmaceutical interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3626 pharmacist\u2010led clinical appointments were analyzed, involving 2442 patients, conducted between May and November 2016 and 2022 in Community Health Centers and patients' homes. Most patients were referred by other health care professionals and were predominantly women aged \u2265\u200960\u2009years using five or more medicines. Overall, 7849 drug\u2010related problems were identified, with a mean of 2.9 problems per patient in 2016 and 3.5 in 2022, mainly related to treatment adherence and clinical monitoring. A total of 17\u2009304 pharmaceutical interventions were performed, with a mean of 7.0 per patient, predominantly involving pharmacotherapeutic counseling. An increase in the number of consultations was associated with higher rates of resolved drug\u2010related problems and improved control of chronic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate the sustainability of pharmacist\u2010led clinical services in a large Brazilian municipality, with measurable benefits for medication management and chronic disease control, supporting the expansion of integrated clinical pharmacy services in PHC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jac5.70251","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:05:11Z","timestamp":1782543911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Pharmacists in Primary Care: A Real\u2010World Experience From S\u00e3o Paulo, Brazil"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-5403","authenticated-orcid":false,"given":"Felipe Tadeu Carvalho","family":"Santos","sequence":"first","affiliation":[{"name":"Research Laboratory on Health Care and Pharmaceutical Policies (LabCare), Department of Pharmacy School of Pharmaceutical Sciences, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Agostinha Murolo","family":"Pierotti","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist Santa Marcelina Health Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayde Lane Mendon\u00e7a","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemia Urruth Le\u00e3o","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Sarmento","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health, Faculty of Medical Sciences State University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60054-8"},{"key":"e_1_2_12_3_1","unstructured":"Brasil. 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