{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:08:31Z","timestamp":1788854911012,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Am Coll Clin Pharm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug\u2010related problems (DRPs) are common in ambulatory prescribing and can cause preventable harm, yet evidence that pharmacist\u2010led interventions reduce clinically meaningful DRPs in Vietnam remains limited. This study evaluated a multifaceted clinical pharmacist intervention to reduce the prevalence and potential clinical harm of DRPs in adult outpatient prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a quasi\u2010experimental pre\u2010post study of electronic adult outpatient prescription records at a tertiary hospital in Ho Chi Minh City, Vietnam. Adult outpatient encounters in which patients were prescribed at least two medicines were consecutively sampled during two 14\u2010day observation periods before and after a 4\u2010week intervention. The intervention combined prospective prescription review with prescriber feedback, targeted education, and reminders. DRPs were classified using the Pharmaceutical Care Network Europe classification. The primary outcome was the prevalence of prescription records with at least one DRP. Secondary outcomes were DRP density and potentially harmful DRPs assessed by expert\u2010panel consensus using the Doerper method. Multivariable logistic regression adjusted for prespecified potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 8832 prescription records were analyzed (pre\u2010intervention, 4586; post\u2010intervention, 4246). Prescriptions with at least one DRP decreased from 65.7% to 37.3% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and mean DRPs per prescription decreased from 1.22\u2009\u00b1\u20091.24 to 0.55\u2009\u00b1\u20090.83 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Prescriptions with potentially harmful DRPs decreased from 2.4% to 1.7% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Reductions occurred across all evaluated DRP subtypes, especially dose selection and administration\u2010timing problems. After adjustment, the post\u2010intervention phase remained associated with lower DRP occurrence (adjusted odds ratio, 0.29; 95% confidence interval, 0.26\u20130.32; the estimated prevalence ratio was 0.57).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A structured, multifaceted clinical pharmacist intervention was associated with substantial reductions in DRP burden and potentially harmful DRPs in outpatient prescribing. These findings support integrating clinical pharmacists into ambulatory care teams as a scalable medication\u2010safety strategy in Vietnam and similar resource\u2010limited health systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jac5.70278","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:30:35Z","timestamp":1788143435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reducing Potentially Harmful Drug\u2010Related Problems in Outpatient Prescribing: A Quasi\u2010Experimental Evaluation of a Multifaceted Clinical Pharmacist Intervention in Vietnam"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9714-2630","authenticated-orcid":false,"given":"Thanh\u2010Tam","family":"Le","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City 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Chi Minh City  Ho Chi Minh City Vietnam"},{"name":"Trung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization \u201cMedication Without Harm: Policy Brief \u201daccessed March 11 2026 https:\/\/www.who.int\/publications\/i\/item\/9789240062764."},{"key":"e_1_2_11_3_1","unstructured":"Pharmaceutical Care Network Europe \u201cClassification for Drug\u2010Related Problems V9.1 \u201daccessed June 10 2026 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