{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:08:29Z","timestamp":1788854909737,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Am Coll Clin Pharm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Psychotropic stewardship programs (\n PSPs<\/jats:styled-content>\n ) have been proposed to optimize psychiatric medication use and improve medication safety; however, data describing their implementation and impact in general medical inpatient settings remain limited. This quality improvement project evaluated a pharmacist\u2010led PSP pilot at an academic medical center.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Adult inpatients were identified using predefined criteria including use of high\u2010risk psychotropic agents (carbamazepine, clozapine, lithium, lamotrigine, valproic acid [\n VPA<\/jats:styled-content>\n ]), scheduled benzodiazepines in patients 65\u2009years and older, and psychotropic polypharmacy (\u2265\u20093 antidepressants or \u2265\u20092 antipsychotics). Pharmacists and prescribers could also identify patients for review. Exclusion criteria included admission to inpatient behavioral health units, active psychiatry consultation, admission to the acute palliative care\/hospice unit, and emergency department status. Over 1\u2009month, a pharmacist conducted chart reviews and collaborated with a psychiatrist to provide recommendations to primary teams. Interventions and outcomes were tracked and summarized using descriptive statistics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During the pilot period, 626 patients were flagged for review; 473 met inclusion criteria and 190 underwent full evaluation. A total of 176 psychotropic stewardship interventions were recommended, of which 162 were accepted (92%). Patients were most identified by direct prescriber\u2010 or pharmacist\u2010initiated review (51.1%) and high\u2010risk psychotropic use (30.1%). Medication reconciliation (29.0%) accounted for the largest proportion of interventions made, followed by dose optimization (26.1%) and medication discontinuation (13.6%). Selective serotonin reuptake inhibitors (\n SSRIs<\/jats:styled-content>\n ) and serotonin\/norepinephrine reuptake inhibitors (\n SNRIs<\/jats:styled-content>\n ) were the most frequently involved medication classes (23.9%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A pharmacist\u2010led\n PSP<\/jats:styled-content>\n was feasible in a general medical inpatient setting and resulted in a high rate of accepted interventions. These findings support the role of pharmacists in improving psychotropic medication safety and highlight opportunities for targeted, system\u2010level interventions. Future work should evaluate clinical outcomes and long\u2010term sustainability of\n PSPs<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jac5.70290","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:29:37Z","timestamp":1788758977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of a Pharmacy\u2010Led Psychotropic Stewardship Pilot Program at an Academic Medical Center"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7717-7321","authenticated-orcid":false,"given":"Olivia","family":"King","sequence":"first","affiliation":[{"name":"Summa Health System Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3186-2212","authenticated-orcid":false,"given":"Jessica","family":"Cather","sequence":"additional","affiliation":[{"name":"Summa Health System Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3592-0120","authenticated-orcid":false,"given":"Paula","family":"Politis","sequence":"additional","affiliation":[{"name":"Summa Health System Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Ivan","sequence":"additional","affiliation":[{"name":"Summa Health System Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Mental Illness","author":"National Institute of Mental 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