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As people with chronic medical conditions often develop mental disorders, it is important to examine the influence of comorbidity of parental physical and mental health conditions on adolescents' functioning. In addition, the physical and mental health status of the spouses\/partners of chronically ill parents needs to be explored to further understand the potential impact of parental chronic illness on adolescents' psychological distress and academic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional data from 164 parent\u2013adolescent pairs were collected through online surveys in the United States between 2018 and 2019. Parent participants (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u2009=\u200942.69, SD\u2009=\u20095.96) included parents who had been diagnosed with a chronic physical illness (e.g., multiple sclerosis, diabetes, chronic pain, cancer). Adolescent participants were middle\u2010 and high\u2010school\u2010aged children who lived with their physically ill parents (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u2009=\u200914.34, SD\u2009=\u20092.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hierarchical regression analyses indicated that comorbid mental illness of parental chronic illness and spousal mental health status were associated with adolescents' distress. The level of physical functioning of chronically ill parents was related to adolescents' academic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parental chronic illness appears to affect adolescents' psychological and academic outcomes through distinct pathways. It is important to examine the comorbid mental health status of chronically ill parents and their spouses'\/partners' mental health conditions to better understand the impact of parental chronic illness on adolescents' psychological adjustment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jad.12282","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T10:23:20Z","timestamp":1701771800000},"page":"381-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Roles of physical functioning and comorbid mental illness of chronically ill parents and their spouses' health status in adolescent functioning"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-5305","authenticated-orcid":false,"given":"Cliff Yung\u2010Chi","family":"Chen","sequence":"first","affiliation":[{"name":"Educational and Community Programs Queens College of the City University of New York Flushing New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5403"},{"key":"e_1_2_9_3_1","unstructured":"Anderson J. 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