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Investigating the link between social media usage and substance use among adolescents is crucial for developing effective interventions and public health policies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized data from the Population Assessment of Tobacco and Health (PATH) study, focusing on adolescents aged between 12 and 17 years old who reported no substance use at Wave 2. Participants were followed from Wave 2 through Wave 5. At baseline (Wave 2), daily time spent on social media use was reported, and past 30\u2010day (P30D) substance use (e.g., alcohol, tobacco products, marijuana, and non\u2010med drug use) was assessed in subsequent waves (Waves 3\u20135). Generalized Estimating Equation (GEE) models were used to analyze self\u2010reported daily time spent on social media and P30D substance use, adjusting for demographic and time\u2010varying covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 4769 adolescents, with nearly half identifying as male (47.0%) and as non\u2010Hispanic white (49.1%). Over 75% of participants reported spending at least 30\u2009min on social media daily. In adjusted models, a dose\u2013response relationship was observed between time spent on social media and the odds of subsequent tobacco use. For alcohol and marijuana use, the association followed a curvilinear pattern, with the highest odds among adolescents who spent 30\u2009min to 3\u2009h per day on social media. For nonmedical drug use, a significant association was observed only for those spending 3\u20136\u2009h on social media daily, who had nearly twice the odds of nonmedical drug use, compared to non\u2010users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study is among the first to quantify the association between daily time spent on social media and the risk of using substances, such as alcohol, cannabis, tobacco products, and illicit drugs in the US adolescent cohort. Social media could be leveraged for targeted interventions and public health initiatives aimed at reducing substance use in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jad.12498","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T13:49:21Z","timestamp":1743947361000},"page":"1314-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Time Spent on Social Media and the Risk of Substance Use Among US Adolescents"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-1820","authenticated-orcid":false,"given":"Xiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Salus Center Saint Louis University Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vaughn","sequence":"additional","affiliation":[{"name":"School of Social Work, Tegeler Hall Saint Louis University Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Salus Center Saint Louis University Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Salus Center Saint Louis University Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10262"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101414"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/tc.2004.009076"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/bs13060475"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Young Adults\u2019 Experiences With Cannabis Retailer Marketing and Related Practices: Differences Among Sociodemographic Groups and Associations With Cannabis Use\u2010Related Outcomes","author":"Berg C. 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