{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:32:50Z","timestamp":1786469570238,"version":"build-2736575974"},"reference-count":113,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R03HD112550"],"award-info":[{"award-number":["R03HD112550"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescence"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>While adverse childhood experiences (ACEs) are robust risk factors for adolescent substance use, the prospective neurocognitive pathways linking both cumulative and specific adversities to substance use remain understudied. This study tested a vulnerability model by examining whether executive function (EF) deficits mediate the link between cumulative and specific ACEs and substance use, and whether this pathway differs for deprivation\u2010 versus threat\u2010based adversities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This longitudinal study used parent\u2010 and youth\u2010report data from the US Adolescent Brain Cognitive Development (ABCD) Study (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094731; M\n                      <jats:sub>age<\/jats:sub>\n                      at baseline\u2009=\u20099.9 years; 52.3% male; 56.5% White, 13.8% Hispanic, 13.1% Black). We tested mediation models with temporally ordered assessments of ACEs (ages 9\u201311), parent\u2010reported EF deficits (12\u201313), and subsequent substance use (13\u201314).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The indirect effect of cumulative ACEs on substance use through EF deficits was significant, accounting for 10% of the total effect. Deprivation\u2010based ACEs (material hardship and emotional neglect) were fully mediated by EF. Several threat\u2010based adversities (e.g., household violence, bullying) also showed full mediation. In contrast, sexual abuse demonstrated a significant direct effect but no significant indirect effect through EF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EF deficits represent a significant pathway from cumulative ACEs to adolescent substance use, supporting a vulnerability model. This pathway appears robust for deprivation\u2010based and many chaotic threat\u2010based adversities, but sexual abuse is an exception that likely operates through non\u2010EF, trauma\u2010specific mechanisms. Prevention efforts should be multifaceted, incorporating EF\u2010focused interventions for at\u2010risk youth while prioritizing trauma\u2010focused care for survivors of sexual abuse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jad.70192","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:10:56Z","timestamp":1780564256000},"page":"1969-1982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-6409","authenticated-orcid":false,"given":"Mahsa P.","family":"Yousefkhani","sequence":"first","affiliation":[{"name":"Department of Human Development and Family Science Syracuse University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiafei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Social Work University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-8947","authenticated-orcid":false,"given":"Sara A.","family":"Vasilenko","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Science Syracuse University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-009-9458-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"Achenbach T. 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