{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:55:04Z","timestamp":1767855304981,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":4018,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2002,1,2]]},"abstract":"<jats:p>Testicular germ cell apoptosis in the cryptorchid testis is induced by abdominal heat stress. p53\u2010dependent apoptosis appears responsible for the initial phase of germ cell loss in experimental cryptorchidism based on a 3\u2010day delay of apoptosis in <jats:italic>p53<\/jats:italic><jats:sup><jats:italic>\u22121\u2212<\/jats:italic><\/jats:sup> mice. However, the mechanisms underlying the subsequent p53\u2010independent apoptosis have not been identified. Although studies have suggested that Fas plays a role in testicular germ cell apoptosis, no direct evidence has been shown. To test the hypothesis that Fas is involved in testicular germ cell apoptosis and is responsible for the p53\u2010independent phase of apoptosis in the cryptorchid testis, <jats:italic>p53<\/jats:italic><jats:sup><jats:italic>\u22121<\/jats:italic><\/jats:sup>, <jats:italic>Ipr\/lpr<\/jats:italic> (a spontaneous mutation in the <jats:italic>Fas<\/jats:italic> gene, which causes autoimmune disease) double\u2010mutant mice were generated and unilateral cryptorchidism was induced in these mice. It was found that testicular weight reduction and germ cell apoptosis were delayed by an additional 3 days, and the Fas production increased in the time frame of p53\u2010independent apoptosis in the experimental cryptorchid testis of wild\u2010type mice. These results suggest that Fas is involved in testicular germ cell apoptosis, and that Fas\u2010dependent apoptosis is responsible for the p53\u2010independent phase of germ cell apoptosis in the cryptorchid testis. The cascade of testicular germ cell apoptosis in response to heat stress implies the existence of sequential quality control mechanisms in spermatogenesis.<\/jats:p>","DOI":"10.1002\/jand.2002.23.1.64","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T16:27:18Z","timestamp":1477067238000},"page":"64-70","source":"Crossref","is-referenced-by-count":82,"title":["p53 and Fas Are Sequential Mechanisms of Testicular Germ Cell Apoptosis"],"prefix":"10.1002","volume":"23","author":[{"given":"Yizhong","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon C.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Dewolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Morgentaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1756"},{"key":"e_1_2_1_3_1","first-page":"557","article-title":"Cancer and male factor infertility","volume":"12","author":"Costabile RA","year":"1998","journal-title":"Oncology (Huntingt)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43942-7"},{"key":"e_1_2_1_5_1","first-page":"160","article-title":"Action of body temperature on the testicle","volume":"3","author":"Fukui N.","year":"1923","journal-title":"Jpn Med World"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70040-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00002-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/clinchem\/41.12.1896","article-title":"Do environmental estrogens contribute to the decline in male reproductive health?","volume":"41","author":"Jensen TK","year":"1995","journal-title":"Clin Chem"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.2.6479"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.5.5110"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7756"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.11.2033"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.1.70"},{"key":"e_1_2_1_14_1","first-page":"29","article-title":"Mammalian spermatogenesis: effect of experimental cryptorchidism in the rat and non-descent of the testis in man","volume":"6","author":"Nelson WO.","year":"1951","journal-title":"Recent Prog Horm Res"},{"key":"e_1_2_1_15_1","first-page":"1217","article-title":"CD95 (Fas\/APO-1) and p53 signal apoptosis independently in diverse cell types","volume":"60","author":"O'Connor L","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050017"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147881"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.3032"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.2.E310"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00253-2"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400490"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0040038"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)33605-6"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.6.1267"},{"key":"e_1_2_1_25_1","first-page":"233","volume-title":"The Testis","author":"VanDemark NL","year":"1970"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod60.2.461"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod58.2.492"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1997.tb01896.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.7.3133"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjand.2002.23.1.64","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjand.2002.23.1.64","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jand.2002.23.1.64","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:44:39Z","timestamp":1700307879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jand.2002.23.1.64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,2]]}},"alternative-id":["10.1002\/jand.2002.23.1.64"],"URL":"https:\/\/doi.org\/10.1002\/jand.2002.23.1.64","archive":["Portico"],"relation":{},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,2]]}}}