{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:52:39Z","timestamp":1788385959848,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T00:00:00Z","timestamp":1121385600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potency of currently used oximes to reactivate sarin\u2010inhibited acetylcholinesterase (AChE) in various parts of pig brain and whole pig brain was evaluated using <jats:italic>in vitro<\/jats:italic> methods. Significant differences in reactivation potency among all tested oximes were observed. At concentrations (10<jats:sup>\u22124<\/jats:sup> M) corresponding to recommended doses <jats:italic>in vivo<\/jats:italic>, the oxime HI\u20106 seems to be a more efficacious reactivator of sarin\u2010inhibited AChE in whole pig brain as well as in cerebral hemispheres and cerebellum compared with the other oximes studied. Nevertheless, there are not any differences in the potency of oximes tested to reactivate sarin\u2010inhibited AChE in medulla oblongata. Thus, the oxime HI\u20106 appears to be the most promising oxime among currently available oximes for the antidotal treatment of acute sarin poisoning, although it is not more efficacious than other currently used oximes in medulla oblongata, whose function is necessary for the vital functions of respiration and circulation. Copyright \u00a9 2005 John Wiley &amp; Sons. Ltd.<\/jats:p>","DOI":"10.1002\/jat.1053","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T09:50:34Z","timestamp":1121421034000},"page":"271-276","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of <i>in vitro<\/i> potency of oximes (pralidoxime, obidoxime, HI\u20106) to reactivate sarin\u2010inhibited acetylcholinesterase in various parts of pig brain"],"prefix":"10.1002","volume":"25","author":[{"given":"Kamil","family":"Kuca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Cabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Kassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Hrabinov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(04)38006-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/009841000156718"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1967.tb09554.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF03035710","article-title":"Toxicity of the combined nerve agents GF\/GB in mice: efficacy of atropine and various oximes as antidotes","volume":"68","author":"Clement JG","year":"1994","journal-title":"Arch. 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